Figure 7.

Biological pathway of complement cascade

Pathway visualization based on Reactome and complemented with details from KEGG and the literature. Tiles illustrate log-fold change values of PD compared with CTRL in liver (left-hand side of tile) and pancreatic islets (right-hand side of tile). Proteins leading the increase of the pathway are marked as driving and are shown in black font and colored tiles. Proteins participating in the pathway and identified from MS proteomics, but not marked as leading edges, are in white tiles, while those in gray were not identified in this analysis.