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. 2022 Sep 13;3(10):100752. doi: 10.1016/j.xcrm.2022.100752

Figure 3.

Figure 3

Gut microbiome and microbiome functional profile correlated with BBIBP-CorV vaccine response

Participants were divided into 2 groups (high group versus low group) according to the ACE2-RBD inhibiting antibody levels at day 42 using the second quartile and the third quartile.

(A) Distribution histograph of the ACE2-RBD inhibiting antibody levels at day 42 (n = 207).

(B) Comparison of ACE2-RBD inhibiting antibody levels at day 42 between the high and low groups (low group, n = 52; high group, n = 52). p values were determined by Mann-Whitney U test.

(C) Weighted Unifrac PCoA 3D plot of samples at day 0 between the high and low groups. The ANOSIM test was used to calculate the significance of dissimilarity (ANOSIM, p = 0.004).

(D) Comparison of the weighted Unifrac range of samples at day 0 between the high and low groups (low group, n = 52; high group, n = 52). The ANOSIM test was used to calculate the significance of dissimilarity (ANOSIM, p = 0.004).

(E) Volcano plot of differentially enriched bacteria at day 0 between samples of the high and low groups (low group, n = 52; high group, n = 52). Pink dots represent bacteria with relatively higher abundance in the high group. Blue dots represent bacteria with relatively higher abundance in the low group. Gray dots represent bacteria with no significant difference between the high and low groups. p values were adjusted by the BH method to control FDR. FDR-adjusted p < 0.05 is shown.

(F) Correlation heatmap of differentially enriched bacteria at day 0 with the clinical characteristics at day 42 (low group, n = 52; high group, n = 52). Pearson correlation analysis with FDR-adjusted p < 0.05 is shown.

(G) Correlation of differentially enriched bacteria at day0 with the ACE2-RBD inhibiting antibody levels at day 42. p values were determined by Pearson correlation analysis (low group, n = 52; high group, n = 52).

(H) Volcano plot of differentially enriched MetaCyc pathways at day 0 between samples from the high and low groups (low group, n = 52; high group, n = 52). p values were adjusted by the BH method to control FDR. FDR-adjusted p < 0.01 is shown.

(I) Correlation heatmap of differentially enriched MetaCyc pathways at day 0, with the clinical characteristics at day 42. Pearson correlation analysis with FDR-adjusted p < 0.05 is shown (n = 207). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.

See also Figures S2 and S3 and Table S4.