Table 1.
Baseline characteristics of participants
| All n = 207 |
Low group (n = 52) |
High group (n = 52) |
P | |
|---|---|---|---|---|
| Gender (%) | 0.273 | |||
| Male | 71 (34.3) | 22 (43.1) | 16 (30.8) | |
| Female | 136 (65.7) | 29 (56.9) | 36 (69.2) | |
| Age, y | 34.0 (29.0–46.0) | 35.0 (29.5–49.0) | 31.0 (27.0–39.5) | 0.071 |
| Height, cm | 162.0 (158.0–169.0) | 165.0 (158.0–171.0) | 162.0 (155.0–170.0) | 0.085 |
| Weight, kg | 59.0 (52.0–67.8) | 63.0 (52.0–70.0) | 56.0 (50.0–68.0) | 0.096 |
| BMI | 22.3 (20.5–24.0) | 22.27 (20.99–23.88) | 22.21 (19.48–24.5) | 0.376 |
| CRP | 5.00 (5.00–5.00) | 5.00 (5.00–5.00) | 5.00 (5.00–5.00) | 0.313 |
| WBC, 109/L | 5.72 (4.87–6.60) | 5.62 (4.95–6.68) | 5.72 (4.93–6.70) | 0.764 |
| Neutrophil ratio, % | 59.1 (54.0–65.3) | 59.3 (55.5–64.5) | 58.3 (53.7–64.9) | 0.470 |
| Lymphocyte ratio, % | 32.1 (26.1–36.8) | 31.8 (27.2–35.5) | 33.3 (26.9–37.7) | 0.380 |
| Monocyte ratio, % | 6.10 (4.90–7.35) | 6.10 (4.95–6.75) | 6.10 (4.55–7.15) | 0.825 |
| Eosinophil ratio, % | 1.50 (0.90–2.50) | 1.40 (0.90–2.35) | 1.35 (0.90–2.28) | 0.784 |
| Basophil ratio, % | 0.44 (0.30–0.60) | 0.40 (0.24–0.50) | 0.40 (0.33–0.60) | 0.078 |
| Neutrophil, 109/L | 3.41 (2.72–4.23) | 3.46 (2.84–4.15) | 3.38 (2.72–4.39) | 0.989 |
| Lymphocyte, 109/L | 1.75 (1.44–2.17) | 1.79 (1.42–2.24) | 1.90 (1.58–2.26) | 0.489 |
| Monocyte, 109/L | 0.34 (0.28–0.42) | 0.34 (0.28–0.40) | 0.36 (0.28–0.46) | 0.611 |
| Eosinophil, 109/L | 0.09 (0.05–0.14) | 0.09 (0.05–0.15) | 0.08 (0.06–0.14) | 0.976 |
| Basophil, 109/L | 0.02 (0.02–0.04) | 0.02 (0.01–0.03) | 0.03 (0.02–0.03) | 0.038 |
| HGB, g/L | 137 (128–147) | 142 (132–148) | 136 (128–144) | 0.130 |
| RBC, 1012/L | 4.53 (4.22–4.88) | 4.66 (4.24–4.94) | 4.50 (4.27–4.85) | 0.470 |
| HCT, % | 40.7 (38.4–42.9) | 42.1 (39.2–43.9) | 40.9 (38.8–42.2) | 0.103 |
| MCV, fL | 90.5 (87.4–93.3) | 89.9 (87.7–92.8) | 91.0 (86.4–93.4) | 0.815 |
| MCH, pg | 30.9 (29.6–31.8) | 30.9 (29.6–31.8) | 30.8 (29.6–31.4) | 0.434 |
| MCHC, g/L | 337 (330–346) | 340 (332–348) | 336 (329–344) | 0.153 |
| RDW-CV, % | 12.6 (12.3–13.1) | 12.6 (12.3–13.1) | 12.5 (12.3–12.9) | 0.424 |
| RDW-SD, fL | 41.7 (39.7–43.7) | 41.9 (39.7–43.9) | 41.0 (39.7–43.3) | 0.278 |
| PLT count, 109/L | 230 (196–268) | 234 (201–276) | 230 (198–257) | 0.810 |
| PCT, % | 0.25 (0.22–0.29) | 0.26 (0.22–0.30) | 0.24 (0.22–0.28) | 0.264 |
| MPV, fL | 10.8 (10.1–11.5) | 11.0 (10.4–11.9) | 10.5 (10.0–11.4) | 0.070 |
| P-LCR, % | 31.2 (26.3–37.8) | 33.2 (27.9–39.9) | 29.4 (25.8–36.9) | 0.076 |
| PDW, % | 13.0 (11.9–14.7) | 13.5 (12.4–15.4) | 12.8 (11.6–14.1) | 0.053 |
| Helper T ratio, % | 35.9 (31.6–41.1) | 35.0 (31.6–38.9) | 34.1 (31.1–41.1) | 0.953 |
| CTL ratio, % | 24.9 (21.0–30.3) | 25.4 (21.0–30.1) | 24.5 (21.2–31.7) | 0.680 |
| ALC per μL | 1,938 (1,553–2,400) | 1,976 (1,576–2417) | 2,034 (1,637–2,559) | 0.371 |
| Total T, per μL | 1,321 (1,074–1,650) | 1,385 (992–1,634) | 1,412 (1,172–1,780) | 0.305 |
| Helper T, per μL | 693 (546–844) | 688 (554–818) | 706 (602–876) | 0.287 |
| CTL count, per μL | 497 (372–642) | 496 (372–644) | 530 (404–728) | 0.384 |
| Total T ratio, % | 69.7 (64.8–74.6) | 68.7 (64.2–74.1) | 70.2 (64.2–74.7) | 0.584 |
| IL-6, pg/mL | 2.40 (2.00–3.35) | 2.20 (2.00–3.00) | 2.70 (2.00–3.42) | 0.077 |
| IL-8, pg/mL | 11.1 (7.32–47.1) | 11.5 (8.89–44.7) | 10.7 (6.43–40.8) | 0.402 |
| TNF-α, pg/mL | 6.30 (5.20–7.70) | 6.60 (5.60–7.55) | 6.10 (4.90–7.43) | 0.174 |
| IgG, g/L | 14.8 (13.0–16.6) | 16.1 (14.6–17.4) | 14.2 (12.0–15.5) | <0.001 |
| IgA, g/L | 2.75 (2.01–3.50) | 2.90 (2.11–3.82) | 2.66 (2.13–3.21) | 0.354 |
| IgM, g/L | 1.29 (0.92–1.71) | 1.15 (0.88–1.48) | 1.42 (1.12–1.88) | 0.008 |
| IgE, IU/mL | 27.0 (12.0–60.0) | 24.0 (14.0–47.0) | 39.0 (14.2–75.2) | 0.148 |
All of these parameters were taken at baseline (day 0). Values are expressed in number (percentage, %) and median (IQR, interquartile range). p values (low group versus high group) were calculated by the Mann-Whitney U test or Fisher exact test as appropriate. p < 0.05 is considered to be statistically significant. BMI, body mass index; CRP, C-reactive protein; WBC, white blood cell; HGB, hemoglobin; RBC, red blood cell; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW-CV, red blood cell distribution width (coefficient of variation); RDW-SD, red blood cell distribution width (SD); PLT, platelet; PCT, plateletcrit; MPV, mean platelet volume; P-LCR, platelet large cell ratio; PDW, platelet distribution width; CTL, cytotoxic T cell; ALC, absolute lymphocyte count; IL, interleukin; TNF, tumor necrosis factor; Ig, immunoglobulin.