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. 2022 Oct 18;3(10):100776. doi: 10.1016/j.xcrm.2022.100776

Figure 2.

Figure 2

Age- and gender- stratified Mendelian randomization analyses

Age- and gender-stratified Mendelian randomization to estimate the causal effects of (A) decreased FN-BMD and (B) Alzheimer’s disease on hip fracture risk. Inverse variance weighted meta-analysis were performed. OR and 95% CIs are for the risk of hip fractures per SD decrease in genetically determined FN-BMD or per doubling of odds of Alzheimer’s disease. Estimates are displayed using a random effects model to account for possible heterogeneity. Age-stratified analyses are divided by the median age (71.2 years) of the hip fracture cases. ∗, the ORs differ as determined by a z test (p < 0.05).