Table 2.
Prenatal ultrasound findings of the study population (fetuses with suspected CoA), according to postnatal outcomes (neonates normal and with CoA).
Variable all patients N = 91 |
No CoA N = 64 |
CoA N = 27 |
p-value |
---|---|---|---|
GA at last fetal ECHO | 35.29 (2.18) | 35.48 (2.24) | 0.72 |
Early CoA diagnosis ( ≤ 28 weeks) | 16 (25%) | 23 (85.2%) | 0.0001 |
Borderline LV | 0 | 10 (37%) | 0.0001 |
Inflow tracts | |||
z-score MV | −2.67 (1, 02) | −3.93 (1, 30) | 0.0001 |
MV/TV ratio | 0.65 (0.09) | 0.51 (0.08) | 0.0001 |
LV/RV ratio | 0.64 (0.08) | 0.53 (0.11) | 0.0001 |
Outflow tract | |||
z-score AV | −0,74(0.94) | −2.22 (1.27) | 0.0001 |
AV/PV ratio | 0,75 (0.30) | 0,56 (0.09) | 0.0001 |
MPA/AA ratio | 1,52 (0.33) | 1,88 (0.26) | 0.0001 |
Aortic Arch (on three vessel view) | |||
AI z-score | −2.26 (1.14) | −3.59 (1.12) | 0.0001 |
Hypoplastic TAA | 9 (14%) | 26 (96%) | 0.0001 |
TAA z-score | 0.71 (1.35) | −1.76 (0.94) | 0.0001 |
AI/AD ratio | 0.51 (0.13) | 0.43 (0.1) | 0.009 |
Functional features | |||
Reversed or mixed flow at the aortic arch | 17 (26.6%) | 13 (48.1%) | 0.05 |
Bidirectional flow at the foramen ovale | 8 (12.5%) | 17 (63%) | 0.0001 |
Associated cardiac anomalies | |||
VSD | 9 (14.1%) | 9 (33.3%) | 0.05 |
Redundant FO membrane | 26 (40.6%) | 5 (18.8%) | 0.05 |
LSCV | 7 (17.9%) | 3 (15%) | 1 |
Bicuspid aortic valve suspicion | 5 (8%) | 10 (37%) | 0.0001 |
Quantitative results are expressed as mean (standard deviation) |
Univariate analysis.