. 2022 Oct 1;12(5):439–454. doi: 10.31661/jbpe.v0i0.2206-1500

Table 4.

Dosimetric results for the organs at risk (OARs) in the three-field (3F), four-field box (4FB), and field-in-field (FIF) treatment planning techniques.

OAR	Parameter	3F	4FB	FIF	P-value
Heart	D_mean (Gy)	20.33±4.79	18.17±4.40	17.16±5.03	0.94 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					0.05 (3F vs. 4FB)
	D_max (Gy)	54.48±1.67	52.81±1.59	51.49±0.77	^*0.01 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	EUD (Gy)	24.04±3.08	22.33±3.99	21.79±3.14	0.49 (4FB vs. FIF)
					^*0.03 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	NTCP (%)	0.05±0.09	0.02±0.04	0.02±0.04	1 (4FB vs. FIF)
					^*0.02 (FIF vs. 3F)
					0.15 (3F vs. 4FB)
Right kidney	D_mean (Gy)	19.24±4.63	14.04±3.80	13.92±3.65	1 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	D_max (Gy)	42.39±5.96	46.10±6.73	45.65±6.63	^*0.02 (4FB vs. FIF)
					0.07 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	EUD (Gy)	9.44±2.26	6.89±1.88	6.76±1.74	1 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	NTCP (%)	< 0.01	< 0.01	< 0.01	1 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
Left kidney	D_mean (Gy)	22.15±3.59	20.06±2.58	20.64±3.27	1 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	D_max (Gy)	52.03±2.11	51.19±0.98	50.65±1.07	0.15 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*0.03 (3F vs. 4FB)
	EUD (Gy)	10.90±1.15	10.22±0.99	10.03±0.77	0.58 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	NTCP (%)	0.05±0.18	0.02±0.07	0.01±0.06	0.35 (4FB vs. FIF)
					0.35 (FIF vs. 3F)
					0.35 (3F vs. 4FB)
Right lung	D_mean (Gy)	10.24±2.76	9.99±2.82	9.86±2.78	0.79 (4FB vs. FIF)
					0.79 (FIF vs. 3F)
					0.79 (3F vs. 4FB)
	Dmax (Gy)	52.52±1.14	51.67±1.47	50.39±1.04	^*<0.01 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	V_{20 Gy} (%)	19.20±3.34	16.87±3.98	17.30±3.61	1 (4FB vs. FIF)
					0.06 (FIF vs. 3F)
					^*0.03 (3F vs. 4FB)
	EUD (Gy)	5.03±1.36	4.91±1.39	4.87±1.36	0.88 (4FB vs. FIF)
					0.88 (FIF vs. 3F)
					0.88 (3F vs. 4FB)
	NTCP (%)	<0.01	<0.01	<0.01	0.76 (4FB vs. FIF)
					0.76 (FIF vs. 3F)
					0.76 (3F vs. 4FB)
Left lung	D_mean (Gy)	10.40±1.39	9.77±1.31	9.56±1.29	0.55 (4FB vs. FIF)
					^*0.01 (FIF vs. 3F)
					0.07 (3F vs. 4FB)
	D_max (Gy)	53.47±1.30	52.69±1.19	51.21±0.70	^*<0.01 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					0.26 (3F vs. 4FB)
	V_{20 Gy} (%)	24.53±7.09	22.02±7.04	21.70±6.99	0.95 (4FB vs. FIF)
					^*0.02 (FIF vs. 3F)
					^*0.02 (3F vs. 4FB)
	EUD (Gy)	5.25±0.70	4.84±0.59	4.73±0.58	0.5 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*0.01 (3F vs. 4FB)
	NTCP (%)	<0.01	<0.01	<0.01	0.44 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*0.04 (3F vs. 4FB)
Liver	D_mean (Gy)	26.30±2.99	29.55±3.20	29.31±3.23	0.77 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					^*<0.01 (3F vs. 4FB)
	D_max (Gy)	52.35±1.43	51.94±1.30	51.42±1.08	0.41 (4FB vs. FIF)
					^*0.03 (FIF vs. 3F)
					0.95 (3F vs. 4FB)
	EUD (Gy)	25.61±1.33	26.49±1.26	26.34±1.27	1 (4FB vs. FIF)
					0.1 (FIF vs. 3F)
					^*0.02 (3F vs. 4FB)
	NTCP (%)	0.56±0.35	0.82±0.41	0.77±0.42	0.64 (4FB vs. FIF)
					^*0.04 (FIF vs. 3F)
					^*0.01 (3F vs. 4FB)
Spinal cord	D_mean (Gy)	22.71±4.02	21.79±4.33	21.56±4.32	^*<0.01 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					0.3 (3F vs. 4FB)
	D_max (Gy)	49.91±1.33	49.60±2.37	49.21±2.49	^*<0.01 (4FB vs. FIF)
					^*<0.01 (FIF vs. 3F)
					0.32 (3F vs. 4FB)
	EUD (Gy)	40.66±1.62	40.32±2.32	39.89±2.39	0.43 (4FB vs. FIF)
					0.16 (FIF vs. 3F)
					0.54 (3F vs. 4FB)
	NTCP (%)	0.04±0.02	0.04±0.03	0.04±0.3	0.62 (4FB vs. FIF)
					0.62 (FIF vs. 3F)
					0.62 (3F vs. 4FB)

OAR: Organ at risk; 3F: Three-field; 4FB: Four-field box; FIF: Field-in-field; EUD: Equivalent uniform dose; NTCP: Normal tissue complication probability

: The P-value is less than 0.05 and this indicates a significant difference between the two techniques