Figure 4.

Antigen- and scaffold-specific antibody responses are not correlated with antigen height, molecular weight, or glycan density

(A–F) Spearman’s correlations between post-second boost (week 10) antigen-specific (A–C) or I53-50 scaffold-specific (D–F) serum IgG levels and antigen height (A and D), molecular weight (B and E), and glycan density (C and F). Shaded areas represent 95% confidence intervals of the plotted linear regression line. Each symbol represents the antigen-specific or I53-50-specific serum IgG geometric mean AUC (AUC GMT) for the indicated nanoparticle immunogen (N = 10 mice per immunogen).