Skip to main content
. 2022 Oct 4;25(11):105275. doi: 10.1016/j.isci.2022.105275

Figure 6.

Figure 6

NF2 mutant increased tumorigenicity

(A) Immunocompromised mice were implanted with WT-IOMM or NF2+/−IOMM meningioma cells.

(B) Growth curve of xenograft tumors from mice implanted with WT-IOMM and NF2+/−IOMM meningioma cells.

(C, C′) Harvests and quantification of xenograft tumors from mice implanted with WT-IOMM and NF2+/−IOMM meningioma cells.

(D, D′, D″, D‴) Immunohistochemistry and quantification of HE, YAP, Ki67 and CD31 of tumor from mice implanted with WT-IOMM and NF2+/−IOMM meningioma cells. Error bars, SEM of three independent experiments. Data are represented as mean ± SEM nsP>0.05, ∗p < 0.05, ∗∗p < 0.01, Student’s t test.