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. 2022 Oct 10;13:1009527. doi: 10.3389/fphar.2022.1009527

FIGURE 2.

FIGURE 2

The effect of multiple TCT on CAP. Acupuncture and taVNS stimulating in ear branch can activate CAP and the reduce inflammatory cytokines; Auricular acupuncture and electroacupuncture “Zusanli” (ST36) increased the activity of local acetylcholine transferase, promoted the transcription and synthesis of ACh, inhibiting the expression of NF-κB in lung tissue and stimulating the CAP in the lung; Moreover, electroacupuncture ST36 activated the vagus nerve pathway connected to the spleen and reduced the production of TNF in the spleen; Electroacupuncture “Hegu” (LI4) activates muscarinic acetylcholine receptor signals in the brain, and then activates the efferent vagus nerve and splenic nerve to activate CAP; Electroacupuncture at “Baihui" (GV20) and “Shenting” (GV24) increase the expression of α7nAChR in hippocampal neurons; The chinese medcine Jiao-Tai-Wan reduced the activity of acetylcholinesterase (AChE) and increase the content of ACh. The ultimate effect of TCT is to activate CAP to reduce the production of inflammatory factors in effector organs to inhibit inflammation.