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. 2022 Jun 23;22(6):912–922. doi: 10.17305/bjbms.2022.7309

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Copyright: © The Author(s) (2022)

This work is licensed under a Creative Commons Attribution 4.0 International License

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Identification of hub genes and their expression patterns in CRC cancer development in TCGA dataset. (A) The bar plot shows results of the GSEA analysis in CRC development; (B) the volcano map presents the CRC-related differential gene distribution; (C) the overall-survival analysis in response to C1QC based on the TCGA database. The survival curve is based on survival and survminer functions. The optimal cutoff values of multiple gene variables are calculated by an automatic cut-off algorithm, and the survival curve is drawn; (D) summary of GSEA analysis of TCGA differential genes: In C7, the immune signature analysis involved in neutrophil activation mainly enriched GSE22886 NEUTROPHIL VS DC UP, GSE22886 NAIVE BCELL VS NEUTROPHIL UP and GSE22886 NEUTROPHIL VS MONOCYTE UP core pathways. Further validation of neutrophil activation in the progression of colon cancer; and (E-G) the biological process, targeted drugs, and pathway enrichment analysis for C1QC.