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. 2022 Oct 10;13:928945. doi: 10.3389/fimmu.2022.928945

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Copyright © 2022 Gravelsina, Vilmane, Svirskis, Rasa-Dzelzkaleja, Nora-Krukle, Vecvagare, Krumina, Leineman, Shoenfeld and Murovska

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Proportion of HHV-6-positive and -negative individuals in the control group and the ME/CFS patient group. (B) Proportion of individuals in the control group and the ME/CFS patient group with detected HHV-6A and HHV-6B. (C) Proportion of HHV-6-positive and -negative patients with different ME/CFS severity; “no”—without HHV-6 genomic sequence in blood DNA, “yes”—with HHV-6 genomic sequence in blood DNA. (D) Number of control individuals and of mild, moderate, and severe ME/CFS disease course patients with viral load < 1,000 copies/10⁶ PBMCs and > 1,000 copies/10⁶ PBMCs. (E) Proportion of control individuals and ME/CFS patients with viral load < 1,000 copies/10⁶ PBMCs and > 1,000 copies/10⁶ PBMCs. f, ,female; m, male.