Table 3.

Summary of functional annotations for 4 SNPs in 6 human diseases (strong epidemiological credibility).

Variant	Gene	Positiona	Annotation	Promoter histone marksb	Enhancer histone marksc	DNAsed	Proteins bounde	Motifs changedf
rs763780	IL17F	52101739	missense	ESDR, BLD	BLD, HRT			Lmo2-complex,Mtf1
rs1889570	IL17F	52110734		ESDR, IPSC, BRST	GI, LIV			HDAC2,NF-I,NRSF
rs2275913	IL17A	52051033		BLD	BLD
rs8193037	IL17A	52051109		BLD, GI	BLD

^achromosome position is based on NCBI Build 37.

^bHistone modification of H3K4me1 and H3K27ac (tissue types: if >3, only the number is included).

^cHistone modification of H3K4me3 (tissue types: if >3, only the number is included).

^dLevels of DNase I hypersensitivity (tissue types: if >3, only the number is included).

^eAlteration in transcription factor binding (disruptions: if >3, only the number is included).

^fAlteration in regulatory motif (disruptions: if >3, only the number is included).