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. 2022 Oct 10;12:1018285. doi: 10.3389/fonc.2022.1018285

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Copyright © 2022 Shen, Li, Zhang, Zhang, Wu, Da, Yang, Wang, Zhang, Qie, Zhao, Lin, Huang, Zhou and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Volcano map representing the up-regulated and down-regulated circRNAs in BCa vs. para-carcinoma tissues (log2(FC) ≥2 or ≤ -2; P< 0.05). (B–D) Based on GSE11224, GSE113786 and GSE113740 datasets, top 50 up-regulated and top 50 down-regulated miRNAs in BCa tissues vs. controls were shown. (E) Venn diagrams revealed the number of overlapping up-regulated (left) or down-regulated (right) miRNAs among GSE11224, GSE113786 and GSE113740. (F, G) Based on two datasets (GSE13507 and GSE37815), top 50 up-regulated and top 50 down-regulated miRNAs in BCa tissues vs. controls were exhibited. (H) Venn diagrams represent overlapping up or down-regulated genes between GSE13507 and GSE37815 datasets. circRNA, circular RNA; miRNA, microRNA; BCa, bladder cancer; FC, fold change.