. 2022 Oct 24;28(2):564–578. doi: 10.1038/s41380-022-01836-9

Table 2.

Estimated marginal mean scores of clinical ratings in controls and Long COVID patients divided into two groups one with highly increased body temperature, lowered SpO2 and high nitro-oxidative stress (LC + O&NS) versus another group with fewer changes in these biomarkers (LC).

Biomarkerse	Controls^A	Cluster 1 or LC (n = 67)	Cluster 2: LC + O&NS (n = 51)	F	df	p
Total HAMD	6.01 (0.82)^B,C	15.24 (0.61)^A,C	20.17 (0.70)^A,B	88.39	2/147	<0.0001
Total HAMA	7.65 (1.27)^B,C	17.78 (0.94)^A,C	23.72 (1.08)^A,B	46.95	2/147	<0.0001
Total FF	7.11 (1.66)^B,C	23.30 (1.24)^A,C	31.06 (1.42)^A,B	61.66	2/147	<0.0001
Depression HAMD	1.65 (0.29)^B,C	4.22 (0.21)^A,C	5.85 (0.25)^A,B	62.39	2/147	<0.0001
Somatic HAMD	1.65 (0.34)^B,C	4.34 (0.26)^A,C	5.92 (0.29)^A,B	44.95	2/147	<0.0001
Anxiety HAMA	1.65 (0.33)^B,C	3.38 (0.25)^A	4.06 (0.28)^A	16.26	2/147	<0.0001
Somatic HAMA	3.17 (0.61)^B,C	7.86 (0.46)^A,C	11.52 (0.53)^A,B	53.57	2/147	<0.0001
Somatic FF	4.61 (1.01)^B,C	15.69 (0.76)^A,C	20.71 (0.87)^A,B	74.64	2/147	<0.0001
Neuropsychiatric symptoms (z score)	−1.167 (0.118)^B,C	0.043 (0.088)^A,C	0.766 (0.101)^A,B	77.78	2/147	<0.001
Autonomic symptoms (z score)	−1.157 (0.122)^B,C	0.139 (0.091)^A,C	0.623 (0.104)^A,B	64.53	2/147	<0.0001
Sleep disorders (z score)	−0.936 (0.141)^B,C	0.022 (0.105)^A	0.591 (0.121)^A	34.10	2/147	<0.0001
Fatigue (z score)	−1.036 (0.136)^B,C	0.167 (0.102)^A	0.519 (0.117)^A	40.42	2/147	<0.0001
Gastro-intestinal symptoms (z score)	−0.915 (0.143)^B,C	0.117 (0.107)^A,C	0.474 (0.123)^A,B	28.59	2/147	<0.0001
Cognitive disorders (z score)	−0.532 (0.163)^B,C	0.074 (0.122)^A	0.257 (0.140)^A	7.22	2/147	0.002

All results are shown as mean (SD) or as ratios. ^A,B,Cposthoc comparisons among group means.

FF Fibro Fatigue scale, HAMD Hamilton Depression Rating Scale, HAMA Hamilton Anxiety Rating Scale; neuropsychiatric symptoms: z unit-based composite score based on FF, HAMD, and HAMA scores.