Fig. 3.

Pathogens and tumor cells cause a dis-regulation in the generation of macrophage phenotypes to escape the immune system. ASFV, African swine flu virus; MTB, mycobacterium tuberculosis; MYXV, myxoma virus; HSV, herpes simplex virus; HIV, human immunodeficiency virus; HCV, hepatitis C virus; TME, tumor microenvironment; DD, death domain; TRADD, TNFR1-associated death domain; FADD, Fas-associated protein with death domain; BID, BH3 interacting domain death; MYD88, myeloid differentiation primary response 88; TRAF6, TNF receptor-associated factor 6; MAPK, mitogen-activated protein kinase, SHP, protein tyrosine phosphatase; vOX2, CD200 viral analogue; vIL-10, viral IL-10 analogue; E2P, E2 viral protein; nef, HIV viral protein; MIF, migration inhibition factor