TABLE 1.
Culture positivity of organs or other specimens from A. fumigatus-infected rabbits during disease progression
| Day and parameter | Urine | Blood | Feces | Left kidney | Right kidney | Spleen | Liver | Lung | Heart |
|---|---|---|---|---|---|---|---|---|---|
| Day 0 | |||||||||
| No. (%) culture positivea | 0/12 (0) | 0/14 (0) | 0/12 (0) | ||||||
| Mean ± SD no. of CFU (n)b | 0 ± 0 (12) | 0 ± 0 (14) | 0 ± 0 (15) | ||||||
| Range of CFU | 0–0 | 0–0 | 0–0 | ||||||
| Day 1 | |||||||||
| No. (%) culture positive | 0/15 (0) | 13/15 (87) | 0/15 (0) | ||||||
| Mean ± SD no. of CFU (n) | 0 ± 0 (15) | 8.0 ± 21.0 (15) | 0 ± 0 (15) | ||||||
| Range of CFU | 0–0 | 0–80 | 0–0 | ||||||
| Day 2 | |||||||||
| No. (%) culture positive | 0/15 (0) | 2/15 (13) | 1/15 (7) | ||||||
| Mean ± SD no. of CFU (n) | 0 ± 0 (15) | 0.05 ± 0.16 (15) | 1.4 ± 5.5 (15) | ||||||
| Range of CFU | 0–0 | 0–0.6 | 0–21.4 | ||||||
| Day 3 | |||||||||
| No. (%) culture positive | 1/15 (7) | 3/14 (21) | 1/15 (7) | 8/8 (100) | 8/8 (100) | 6/8 (75) | 6/8 (75) | 7/8 (88) | 5/7 (71) |
| Mean ± SD no. of CFU (n) | 0.13 ± 0.52 (15) | 0.04 ± 0.07 (14) | 0.45 ± 1.73 (15) | 4.9 ± 13.4 (8) | 2.9 ± 2.1 (8) | 3.8 ± 4.4 (8) | 3.3 ± 4.7 (8) | 1.8 ± 2.9 (8) | 0.08 ± 0.07 (7) |
| Range of CFU | 0–2.0 | 0–0.2 | 0–6.7 | 0.11–38.0 | 0.55–6.0 | 0–11.0 | 0–13.3 | 0–8.4 | 0–0.18 |
| Day 4 | |||||||||
| No. (%) culture positive | 1/7 (14) | 3/6 (50) | 1/7 (14) | 7/7 (100) | 7/7 (100) | 7/7 (100) | 7/7 (100) | 7/7 (100) | 4/7 (57) |
| Mean ± SD no. of CFU (n) | 0.29 ± 0.77 (7) | 0.37 ± 0.51 (6) | 1.36 ± 3.59 (7) | 7.1 ± 7.3 (7) | 7.8 ± 7.4 (7) | 11.2 ± 8.3 (7) | 2.7 ± 1.9 (7) | 2.0 ± 1.2 (7) | 0.14 ± 0.22 (7) |
| Range of CFU | 0–2.0 | 0–0.8 | 0–9.5 | 0.44–17.0 | 1.2–18.0 | 1.5–23.0 | 0.61–5.8 | 0.38–3.0 | 0–0.6 |
a
Number (percent) of rabbits whose organ or other specimen was culture positive.
b
Mean ± SD number of CFU per milliliter for blood and urine and per gram (wet weight) for organs and feces for the number (n) of rabbits indicated in parentheses; rabbits were euthanatized and necropsied on day 3 or 4 after infection.