. Author manuscript; available in PMC: 2022 Oct 24.

Published in final edited form as: Toxicology. 2021 May 10;457:152819. doi: 10.1016/j.tox.2021.152819

Table 3.

Measured in vitro clearance rates (µL/min/10⁶ hepatocytes) for test chemicals by species and starting substrate concentration

Test chemical	CAS #	Human		Rat		Trout
Test chemical	CAS #	0.1 µM	1 µM	0.1 µM	1 µM	0.1 µM	1 µM

1,3-Benzenedicarboxylic acid	121-91-5	^c	^c	^c	1.44^a
2,2’,4,4’-Tetrahydroxybenzophenone	131-55-5			>103^d	>232^d	>89.8^d	29.0^a
2,5-Di-tert-butylbenzene-1,4-diol	88-58-4	2.75^a	8.91^a	^e	^c
2-Ethylhexyl paraben	5153-25-3	>128^d	178^a			62.0^a	29.5^a
3,3’,5,5’-Tetrabromobisphenol A	79-94-7	3.22^a	5.84^a	15.2^a	23.0^a	25.3^a	22.3^a
4-(1,1,3,3-Tetramethylbutyl) phenol	140-66-9					55.9^a	60.9^b
4,4’-Sulfonylbis[2-(prop-2-en-1-yl) phenol]	41481-66-7	84.7^d	89.4^a	80.4^a	77.6^a	^f	^f
4-Hexylresorcinol	136-77-6	^f	^f	>227^b	214^a
4-Nitroaniline	100-01-6	3.68^a	<2.57^a	f	<5.07^a	<2.80^a	<3.38^a
4-n-Nonylphenol	104-40-5	62.6^b	76.4^b	>110^b	121^b	^e	^e
4-Nonylphenol (branched)	84852-15-3	>104^b	141^b			^g	^g
4-Octylphenol	1806-26-4					^g	11.4^a
6:2 Fluorotelomer alcohol	647-42-7	^e	^e	^e	^e	^e	^e
Atrazine	1912-24-9			14.1^a	12.4^a	<2.80^a	<3.38^a
Benzyl butyl phthalate	85-68-7	^e	^e			^g	^g
Benzylparaben	94-18-8	>192^d	>356^a	^e	^e
Bisphenol A	80-05-7					>103^a	37.4^a
Bisphenol AF	1478-61-1			165^b	194^a	>81.1^a	37.1^a
Celecoxib	169590-42-5	24.6^a	22.9^a	<2.93^a	2.97^a
Cymoxanil	57966-95-7	^e	^e	^e	^e
Dapsone	80-08-0	1.15^a	0.92^a	1.39^a	1.46^a
Deltamethrin	52918-63-5	^e	^c	^e	^e	2.43^d	2.96^a
Di(2-ethylhexyl) phthalate	117-81-7	^g	^c			^f	4.49^a
Dibutyl phthalate	84-74-2			>79.3^b	^e	^f	>104^b
Dichlobenil	1194-65-6					^f	^f
Dicumyl peroxide	80-43-3	^e	^e	^e	^e	^c	9.18^a
Ethylparaben	120-47-8					53.9^a	11.2^a
Fenthion	55-38-9	^e	^e	>244^b	^e	^e	^f
Heptylparaben	1085-12-7	^f	^f	^f	150^d	33.0^b	39.9^a
Hexaflumuron	86479-06-3	^f	5.20^d	^f	^f	^c	<3.38^d
Hydroxyflutamide	52806-53-8	<3.43^d	<2.57 ^a	<2.93^a	<5.07^a	<2.80^d	<3.38^a
Ipconazole	125225-28-7	>242^a	106^a			1.94^a	2.06^a
Isofenphos	25311-71-1	^e	^e	^e	^e	^e	^e
Kaempferol	520-18-3	>95.7^a	181^b
Mestranol	72-33-3	10.2^a	^c	>154^b	243^b
Metconazole	125116-23-6	16.7^a	4.19^a			1.14^a	0.96^a
Methoxychlor	72-43-5			^e	^e	3.55^a	3.40^a
Myclobutanil	88671-89-0			91.1^a	68.1^a	0.67^a	0.46^a
Octyl gallate	1034-01-1	^g	^g	^g	^g	^g	^g
p,p’-DDE	72-55-9	^c	^e	^e	^e	1.49^a	2.11^a
Phenthoate	2597-03-7	>168^a	>343^b	^e	^e	26.6^a	18.1^d
Phoxim	14816-18-3	^e	^e	^e	^e	^f	1.80^a
Picoxystrobin	117428-22-5	38.2^a	19.4^a	88.4^b	62.3^b
Propargite	2312-35-8	^e	^e	^e	^e
Propiconazole	60207-90-1			>232^a	164^d	1.12^a	0.88^a
Simazine	122-34-9					<2.80^a	<3.38^a
Terbuthylazine	5915-41-3	4.10^a	2.59^a	12.9^a	8.57^a
Triclocarban	101-20-2	9.45^a	6.36^a	38.4^a	20.5^a	^c	2.99^a
Triclosan	3380-34-5					64.1^a	39.4^b
Trimethyl phosphate	512-56-1	<3.43^a	<2.57^a	<2.93^a	<5.07^a
Triphenyl phosphate	115-86-6			>126^b	140^a	5.01^a	^c
Triphenyl phosphite	101-02-0	^e	^e	^e	^e
Triphenylethylene	58-72-0	^e	^e	^e	^e	14.0^a	5.00^a
Zearalenone	17924-92-4	>138^a	211^a	>146^a	213^a	28.4^b	14.4^a

HTC 80 to 120%

HTC between 50 and 80%, and ratio >10

HTC between 50 and 80%, and ratio <10, no rate reported

HTC between 120 and 130%

HTC <50%, no rate reported

HTC >130%, no rate reported

Analytical or technical issues, no rate reported

Grey = not run