Table 4.
Comparison of measured in vitro clearance rates (µL/min/106 hepatocytes) with other published values
| Test chemical | CAS # | Measured value | Test conc. (µM) | Published valueh | Test conc. (µM) | Reference |
|---|---|---|---|---|---|---|
|
| ||||||
| Human | ||||||
|
| ||||||
| 2,5-Di-tert-butylbenzene-1,4-diol | 88-58-4 | 8.91a 2.75a |
1 0.1 |
9.86 117 |
10 1 |
Wambaugh et al., 2019 |
| 3,3’,5,5’-Tetrabromobisphenol A | 79-94-7 | 5.84a 3.22a |
1 0.1 |
13.6 50.5 |
10 1 |
Wambaugh et al., 2019 |
| 4-Nitroaniline | 100-01-6 | <2.57a 3.68a | 1 0.1 |
8.62 23.6 |
10 1 |
Wambaugh et al., 2019 |
| Benzyl butyl phthalate | 85-68-7 |
e
e |
1 0.1 |
309 465 |
10 1 |
Wambaugh et al., 2019 |
| Benzylparaben | 94-18-8 | >356a >192d | 1 0.1 |
312 633 |
10 1 |
Wambaugh et al., 2019 |
| Celecoxib | 169590-42-5 | 22.9a 24.6a |
1 0.1 |
25.7 | 1 | Temesi et al., 2010 |
| Cymoxanil | 57966-95-7 |
e
e |
1 0.1 |
5.05 32.8 |
10 1 |
Wambaugh et al., 2019 |
| Dapsone | 80-08-0 | 0.92a 1.15a |
1 0.1 |
0.00 0.00 |
10 1 |
Wambaugh et al., 2019 |
| Di(2-ethylhexyl) phthalate | 117-81-7 |
c
g |
1 0.1 |
0.00 0.00 |
10 1 |
Wetmore et al., 2012 |
| Fenthion | 55-38-9 |
e
e |
1 0.1 |
21.6 87.2 |
10 1 |
Wetmore et al., 2012 |
| Hydroxyflutamide | 52806-53-8 | <2.57a <3.43d | 1 0.1 |
0.00 0.00 |
10 1 |
Wambaugh et al., 2019 |
| Ipconazole | 125225-28-7 | 106a
>242a |
1 0.1 |
17.8 101 |
10 1 |
Wambaugh et al., 2019 |
| Isofenphos | 25311-71-1 |
e
e |
1 0.1 |
25.4 158 |
10 1 |
Wambaugh et al., 2019 |
| Octyl gallate | 1034-01-1 |
g
g |
1 0.1 |
158 230 |
10 1 |
Wambaugh et al., 2019 |
| p,p’-DDE | 72-55-9 |
e
c |
1 0.1 |
87.0 199 |
10 1 |
Wambaugh et al., 2019 |
| Propargite | 2312-35-8 |
e
e |
1 0.1 |
22.1 24.0 |
10 1 |
Wambaugh et al., 2019 |
|
| ||||||
| Rat | ||||||
|
| ||||||
| 4-n-Nonylphenol | 104-40-5 | 121b >110b |
1 0.1 |
11.7 | 2 | Han et al., 2007 |
| Atrazine | 1912-24-9 | 12.3a 14.1a |
1 0.1 |
63.5 | 1 | Han et al., 2007 |
| Benzylparaben | 94-18-8 |
e
e |
1 0.1 |
639 | 1 | Honda et al., 2019 |
| Deltamethrin | 52918-63-5 |
e
e |
1 0.1 |
7 | 1 | Honda et al., 2019 |
| Heptylparaben | 1085-12-7 | 150d
f |
1 0.1 |
311 | 1 | Honda et al., 2019 |
| Trimethyl phosphate | 512-56-1 | <5.07a <2.93a | 1 0.1 |
0 | 1 | Honda et al., 2019 |
| Zearalenone | 17924-92-4 | 213a >146a |
1 0.1 |
59.5 | 1 | Honda et al., 2019 |
|
| ||||||
| Trout | ||||||
|
| ||||||
| 4-n-Nonylphenol | 104-40-5 |
e
e |
1 0.1 |
1 15.3 |
2 10 |
Nichols et al., 2018
Mingoia et al., 2010 |
| Atrazine | 1912-24-9 | <3.38a <2.80a | 1 0.1 |
0.033 | 2 | Han et al., 2007 |
| Deltamethrin | 52918-63-5 | 2.96a 2.43d |
1 0.1 |
2.55 9.06 |
1 1 |
Nichols et al., 2018 |
| Fenthion | 55-38-9 |
f
e |
1 0.1 |
3.4 43 |
0.2 2 |
Nichols et al., 2018
Fay et al., 2014a |
| Methoxychlor | 72-43-5 | 3.40a 3.55a |
1 0.1 |
0.37 2.35 |
0.32 2 |
Fay et al., 2014a
Nichols et al., 2018 |
a
HTC 80 to 120%
b
HTC between 50 and 80%, and ratio >10
c
HTC between 50 and 80%, and ratio <10, no rate reported
d
HTC between 120 and 130%
e
HTC <50%, no rate reported
f
HTC >130%, no rate reported
g
Analytical or technical issues, no rate reported
h
Lowest and highest intrinsic clearance values found in the literature with respective starting substrate concentration (Test conc.; µM) and reference