KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse anti-BRAF	Santa Cruz	F-7: sc-5284
Chemicals, Peptides, and Recombinant Proteins
Vemurafenib	MedChemExpress	HY-12057
Encorafenib	MedChemExpress	HY-15605
Dabrafenib	Selleckchem	S2807
PLX8394	MedChemExpress	HY-18972
Benzyl-coelenterazine	Nanolight	301
Transfectin	BioRad	1703352
Deposited Data
K* designs, mutational signatures	This studyAlexandrov et al. 2013	https://doi.org/10.7910/DVN/DA0WWK ftp://ftp.sanger.ac.uk/pub/cancer/AlexandrovEtA
Coding sequence for wt targets	COSMIC, Bamford et al. 2004	http://cancer.sanger.ac.uk/cosmic
COSMIC mutation data, version 95	COSMIC, Bamford et al. 2004	http://cancer.sanger.ac.uk/cosmic
cBioPortal mutation data, version 4.0.3	Cerami et al. 2012	https://www.cbioportal.org/
Structures of the target-ligand complexes	The Protein Data Bank This study	http://www.rcsb.org/pdb/home/home.do https://doi.org/10.7910/DVN/DA0WWK
OSPREY-predicted structures of the kinase:ligand complexes	This study	https://doi.org/10.7910/DVN/DA0WWK
Experimental Models: Cell Lines
HEK293T	ATCC	N/A
Recombinant DNA
KinCon PCA reporters	This paper Roeck et al, 2019	N/A
Software and Algorithms
OSPREY 3	Hallen et al. 2018	https://doi.org/10.7910/DVN/DA0WWK
Maestro Release 2021-1	Schrödinger	https://www.schrodinger.com/products/maestro
AmberTools21	Case et al. 2021	https://ambermd.org/GetAmber.php#ambertools
GOLD version 5.8.0	Jones et al. 1997	https://www.ccdc.cam.ac.uk/solutions/csd-discovery/Components/Gold/
MOE 2015.1001	Chemical Computing Group	https://www.chemcomp.com/