Table 1.
Natural products targeting ATR/CHK1 signaling pathway as anticancer agent.
| Secondary metabolites | Class of compound | Sources | Cell lines | IC50in vitro | References |
|---|---|---|---|---|---|
| ATR-CHK1 activation | |||||
| Resveratrol | Stilbenoid (Polyphenol) | Vitis vinifera (fruit) | TK6 and WTK1 | 30 μM | [83] |
| Resveratrol | Ovcar-3, PA-1 | 50 μM | [82] | ||
| Resveratrol | SKOV-3 | 30 μM | [82] | ||
| Resveratrol analogue (E)− 8-acetoxy-2-[2-(3,4-diacetoxyphenyl) ethenyl]- quinazoline (8-ADEQ) | HeLa | 8 μM | [84] | ||
| Mangiferin | Flavonoid | Mangifera indica (leaves and bark) | HL-60 | 160 μM | [76] |
| Harmine | Tricyclic b-carboline alkaloid | Peganum harmala (seeds) | Hep3B | 20 μM | [70] |
| Rocaglamide-A (Roc-A) | Flavagline | Aglaia Sp. | HL-60, Jurkat-16, CEM, Molt-4 and DND41; Hut-78, L1236; HepG2 and Huh7; HT-29 and HCT116; PC3; MCF-7 | 50–100 nM | [68] |
| ATR-CHK1 inhibition | |||||
| Kaempferol | Flavonoid | berries, grapefruit, and Ginkgo biloba | HL-60 | 75 μM | [75] |
| Curcumin | Flavonoid | Curcuma longa (rhizome) | HEK293E | 493 nM | [81] |
| Curcumin | Flavonoid | Curcuma longa(rhizome) | HeLa, HT1080, H1299 | 15 μM | [81] |
| Protoapigenone (WYC02) | Flavonoid | Thelypteristorresiana (whole plant) | MDA-MB-231 | 8 μmol/L |
[78] |
| A549 | 12 μmol/L | [78] | |||
| Protoapigenone Synthetic derivative (WYC0209) | Flavonoid | MDA-MB-231 | 2 μmol/L | [78] | |
| A549 | 4 μmol/L | [78] | |||
| AF4 (apple peel flavonoid fraction) | Flavonoid | Malus domestica (peel) | BEAS-2B | 50 μg /mL | [73] |
| Triptolide | Diterpenoid triepoxide | Tripterygium wilfordii (whole plant) | A375. S2 | 30 nM | [74] |
| Caffeine | Alkaloid | Theobroma cacao(seeds) | A549 | 1.1 mM | [71] |
| Schisandrin B | Dibenzocyclooctadiene lignin | Schisandra chinensis (fruits) | A549 | 7.25 μM | [72] |