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. 2022 Oct 15;2022:9252319. doi: 10.1155/2022/9252319

Figure 5.

Figure 5

BTG2 is significantly downregulated in the articular cartilage of OA guinea pig. (a) GEO database was applied to predict OA-related genes through common selection of GES12021, GSE55235, and GES55457 with logFC < (-1.0) and P < 0.05. (b) qRT-PCR was used to examine the expression of the nine selected genes (GRB10, BTG2, APOLD1,KLF9, MCL1, VEGFA, SIK1, GADD45B, and TNFAIP3) in the OA group (n = 8) compared with the Sham group (n = 4). (c) BTG2 expression in the articular cartilage obtained from guinea pigs in four groups (NS, SH, MSC, and control) after 3 or 8 weeks of injections. N = 4 in the control group; N = 8 in other three groups. ∗P < 0.05. ∗∗P < 0.01. (d) Western blot assay was conducted to verify the protein level of BTG2 among the different animal groups in different time point. N = 3 in each group.