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. 2022 Oct 23;10:151. doi: 10.1186/s40478-022-01451-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Humanized anti-sCD146 antibody mucizumab significantly decreases U87 cell proliferation, migration and invasion and hampers CSC and EMT in vitro. U87 cells were treated with conditioned media (CM) containing Irrelevant IgG, bevacizumab (Avastin), Mucizumab, or combination of both antibodies for proliferation (a), migration (b), and invasion assays (c). EMT and CSC markers were also examined at the mRNA (d and e) and protein (f and g) levels. Average of 3 experiments is shown; *p < 0.05, **p < 0.01, ***p < 0.001, experimental vs control