Table 3.
The mediation effects of lipid peroxidation and inflammation on the ultrafine particles (UFP)-associated thromboxane B2 increase in the participants with and without COPD
| Mediators | COPD | Non-COPD | ||
|---|---|---|---|---|
| Mediation proportions (95% CI) |
P | Mediation proportions (95% CI) |
P | |
| 12-HETE | 0.35 (0.06, 0.72) | 0.04 | 0.61 (− 3.48, 2.16) | 0.46 |
| 15-HETE | 0.33 (0.07, 0.56) | 0.02 | 0.8 (− 4.86, 6.36) | 0.42 |
| IL-1β | 0 (− 0.04, 0.07) | 0.86 | − 0.02 (− 0.44, 0.65) | 0.70 |
| IL-8 | 0 (− 0.08, 0.07) | 0.86 | 0.12 (− 1.04, 2.81) | 0.54 |
| MCP-1 | 0.03 (− 0.07, 0.13) | 0.28 | 0.01 (− 0.73, 0.37) | 0.78 |
| MIP-1α | 0.03 (− 0.04, 0.16) | 0.36 | 0.1 (− 1.07, 4.08) | 0.52 |
| MIP-1β | 0.05 (− 0.02, 0.14) | 0.16 | 0.02 (− 0.43, 2.08) | 0.80 |
| TNF-α | 0.04 (− 0.08, 0.19) | 0.58 | 0.02 (− 2.07, 2.61) | 0.88 |