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. 2022 Oct 23;23:75. doi: 10.1186/s12863-022-01090-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A use case illustrating the retrieval of the “dishevelled” gene from EchinoDB that contains orthocluster data from 42 different echinoderm species and EchinoidDB that contains biological data of the green sea urchin L. variegatus. Dishevelled (Dvl) gene functions as a principal component of the Wnt signaling pathway that governs several cellular processes, including cell proliferation, cell differentiation, and apoptosis or cell death. a Results after searching for the keyword “dishevelled” in EchinoDB (https://echinodb.uncc.edu) [18]. In this example, the search was conducted against the repository of clusters of orthologous genes discovered from echinoderm transcriptomes. A selected record will be highlighted, and amino acid sequences from the orthocluster repository will be displayed. b Displays amino acid sequence clusters of the selected orthologous record of the “dishevelled” gene group from the EchinoDB repository. c Screenshot of the EchinoidDB main page (https://echinodb.uncc.edu/SUrchinApp/) [23]. The image shows the results after searching for the keyword “dishevelled” against the database of the green sea urchin L. variegatus. The interface allows the selection of any record on the results page to view the sequence. d Example amino acid sequence from selected record in EchinoidDB