Skip to main content
. 2022 Oct 23;23:75. doi: 10.1186/s12863-022-01090-6

Table 2.

Key components of the Wnt signaling pathway retrieved from the database. For each gene, we list the gene name, the gene group it belongs to, and its role in the pathway. In addition, for each resource – EchinoDB, EchinoidDB, and OphiuroidDB – we show the number of sequences retrieved using keyword and BLAST search. Column search type represents K for keyword search and B for BLAST search. Number 0 indicates that no sequence was found in the database for that gene

Group Gene Function Name Search Type EchinoDB EchinoidDB OphiuroidDB Cite
Regulator Negative regulator. Part of the β-catenin destruction complex APC B 32 2 1 [73]
Regulator Negative regulator. Part of the β-catenin destruction complex Axin K 54 1 2 [73]
Regulator Phosphorylates β-catenin and the cytoplasmic tail of LRP. Part of the β-catenin destruction complex CK1 B 225 4 2 [73]
Regulator Negative regulator. Binds to LRP Dickkopf B 2 2 2 [73]
Regulator Mediates the recruitment of Axin to the plasmalemma in the ON state of the pathway Dishevelled K 68 1 4 [73]
Receptor Wnt receptors Frizzled B 500 8 7 [73, 84]
Regulator Negative regulator. Transcriptional co-repressor. Binds to TCF in the OFF state of the pathway Groucho K 330 6 3 [73]
Regulator Phosphorylates β-catenin and the cytoplasmic tail of LRP. Part of the β-catenin destruction complex GSK3 K 56 1 0 [73]
Receptor Dickkopf receptor. Mediates repression of the Wnt pathway Kremen B 413 45 49 [73, 85]
Regulator Pathway enhancer. Receptor for R-spondin Lgr5 B 500 1 4 [73]
Receptor Wnt co-receptor LRP B 165 11 9 [73]
Ligand Alternative ligand for the Wnt receptors Norrin B 3 0 0 [73]
Regulator Negative regulator. Inactivates Wnt in the extracellular space through enzymatic action Notum (Wingful) K 43 1 0 [73, 86]
Modifier Palmitoyl transferase, attaches palmitoleic acid to Wnt Porcupine K 23 1 1 [73]
Regulator Negative regulator. Wnt target gene Rnf43 B 189 7 9 [73]
Regulator Pathway enhancer R-spondin K 12 1 1 [73]
Regulator Negative regulator. Binds to LRP Sclerostin K 17 1 1 [73]
Regulator Negative regulators. Sequester Wnts in the extracellular space sFRPs B 153 4 4 [84]
Transcription Factor Transcriptional factors regulated by the Wnt pathway. Repress the target genes in the OFF state. Acitvate transctiption of the same genes in the ON state TCF/Lef K 48 2 1 [73]
Receptor Norrin-specific co-receptor Tspan12 B 146 5 4 [73]
Ligand Paracrine/juxtacrine signaling molecules Wnt K 10 10 7 [73, 84]
Auxiliary protein Specific intracellular transporter of Wnts Wntless/Evi (Wls) K 44 2 1 [73]
Regulator Negative regulator. Wnt target gene Znrf3 B 234 1 1 [73]
Regulator Main modulator of the pathway β-catenin K 255 3 1 [73]
Regulator Ubiquitinates the phosphorylate β-catenin thus targeting it for proteosomal destruction β-TrCP B 33 5 2 [73]