Regulator |
Negative regulator. Part of the β-catenin destruction complex |
APC |
B |
32 |
2 |
1 |
[73] |
Regulator |
Negative regulator. Part of the β-catenin destruction complex |
Axin |
K |
54 |
1 |
2 |
[73] |
Regulator |
Phosphorylates β-catenin and the cytoplasmic tail of LRP. Part of the β-catenin destruction complex |
CK1 |
B |
225 |
4 |
2 |
[73] |
Regulator |
Negative regulator. Binds to LRP |
Dickkopf |
B |
2 |
2 |
2 |
[73] |
Regulator |
Mediates the recruitment of Axin to the plasmalemma in the ON state of the pathway |
Dishevelled |
K |
68 |
1 |
4 |
[73] |
Receptor |
Wnt receptors |
Frizzled |
B |
500 |
8 |
7 |
[73, 84] |
Regulator |
Negative regulator. Transcriptional co-repressor. Binds to TCF in the OFF state of the pathway |
Groucho |
K |
330 |
6 |
3 |
[73] |
Regulator |
Phosphorylates β-catenin and the cytoplasmic tail of LRP. Part of the β-catenin destruction complex |
GSK3 |
K |
56 |
1 |
0 |
[73] |
Receptor |
Dickkopf receptor. Mediates repression of the Wnt pathway |
Kremen |
B |
413 |
45 |
49 |
[73, 85] |
Regulator |
Pathway enhancer. Receptor for R-spondin |
Lgr5 |
B |
500 |
1 |
4 |
[73] |
Receptor |
Wnt co-receptor |
LRP |
B |
165 |
11 |
9 |
[73] |
Ligand |
Alternative ligand for the Wnt receptors |
Norrin |
B |
3 |
0 |
0 |
[73] |
Regulator |
Negative regulator. Inactivates Wnt in the extracellular space through enzymatic action |
Notum (Wingful) |
K |
43 |
1 |
0 |
[73, 86] |
Modifier |
Palmitoyl transferase, attaches palmitoleic acid to Wnt |
Porcupine |
K |
23 |
1 |
1 |
[73] |
Regulator |
Negative regulator. Wnt target gene |
Rnf43 |
B |
189 |
7 |
9 |
[73] |
Regulator |
Pathway enhancer |
R-spondin |
K |
12 |
1 |
1 |
[73] |
Regulator |
Negative regulator. Binds to LRP |
Sclerostin |
K |
17 |
1 |
1 |
[73] |
Regulator |
Negative regulators. Sequester Wnts in the extracellular space |
sFRPs |
B |
153 |
4 |
4 |
[84] |
Transcription Factor |
Transcriptional factors regulated by the Wnt pathway. Repress the target genes in the OFF state. Acitvate transctiption of the same genes in the ON state |
TCF/Lef |
K |
48 |
2 |
1 |
[73] |
Receptor |
Norrin-specific co-receptor |
Tspan12 |
B |
146 |
5 |
4 |
[73] |
Ligand |
Paracrine/juxtacrine signaling molecules |
Wnt |
K |
10 |
10 |
7 |
[73, 84] |
Auxiliary protein |
Specific intracellular transporter of Wnts |
Wntless/Evi (Wls) |
K |
44 |
2 |
1 |
[73] |
Regulator |
Negative regulator. Wnt target gene |
Znrf3 |
B |
234 |
1 |
1 |
[73] |
Regulator |
Main modulator of the pathway |
β-catenin |
K |
255 |
3 |
1 |
[73] |
Regulator |
Ubiquitinates the phosphorylate β-catenin thus targeting it for proteosomal destruction |
β-TrCP |
B |
33 |
5 |
2 |
[73] |