Table 3.

Key components of the Notch signaling pathway retrieved from the database. Each line corresponds to the gene name, gene group, and its role in the pathway. In addition, we list the number of sequences retrieved from EchinoDB, EchinoidDB and OphiuroidDB using “keyword” and “BLAST” search. Column search type represents K for keyword search and B for BLAST search. Number 0 represents no sequence found in the corresponding database for that gene

Group	Gene Function	Name	Search Type	EchinoDB	EchinoidDB	OphiuroidDB	Cite
Motif	A disintegrin and metalloproteinase with thrombospondin motifs	ADAM 10/17	K	344	2	83	[72]
Receptor	Receptor proteolysis	Presenilin 1	K	77	2	3	[16, 72]
Transcription factor	HES-4-like	HES	K	46	3	3	[16]
Auxiliary protein	Mastermind-like protein. Co-activator of RBP-J	Mastermind	B	122	8	6	[72, 87]
Enzyme	E3 ubiquitin-protein ligase	Mindbomb	K	282	188	367	[16]
Protein coding	Notch Activation Complex Kinase. Co-activator of RBP-J	NACK	K	68	3	6	[16]
Transcription factor	CREB-binding protein. Co-activator of RBP-J	p300	K	103	2	2	[16]
Receptor	Neurogenic locus notch	Notch	K	14	35	50	[72, 88]
Receptor	Receptor proteolysis	Nicastrin	K	68	1	1	[72, 89]
Regulator	Negative regulator of the Notch pathway	Numb	K	68	0	1	[89]
Regulator	Context-dependent positive or negative regulator	Notchless	K	200	1	10	[90]
Regulator	Neuronal precursor cell-Expressed. Targets Notch and Deltex for degradation	Nedd4	K	94	2	2	[91]
Regulator	E3 ubiquitin-protein ligase/ DTX1. Context-dependent positive or negative regulator. Antagonizes Nedd4	Deltex	K	139	0	0	[74, 91]
Transcription factor	Mesoderm posterior bHLH transcription factor 2. Activates Fringe, induces degradation of Mastermind	Mesp2	B	6	2	1	[88]
Ligand	Ubiquitination of Jagged	Neuralized	K	159	6	26	[16]
Receptor	Ligand of the notch receptor	Delta/Serrate (Jagged)	K	68	2	2	[16]
Transcription factor	CBF1/ Recombination signal binding protein for immunoglobulin kappa J region. Transcription factor activated by Notch	RBP-J	K	1	1	0	[16, 72]
Regulator	Numb-associated kinase. Positive regulator of the Notch pathway	NAK	B	500	39	78	[16, 72]
Activator	Acyl-CoA-Binding Domain-Containing Protein 3. Activator of Numb	ACBD3	B	132	1	1	[16, 72]
Ligand	Ligand of Numb Protein 2. Negative regulator of Numb	LNX2	K	54	1	1	[72, 87]
Protein	Hairy/enhancer-of-split related with YRPW motif protein 1. Canonical target gene.	HEY1	K	24	3	1	[16]
Receptor	Paired basic amino acid cleaving enzyme. Receptor proteolysis	Furin	B	342	6	11	[16, 72]
Modifier	Protein O-glucosyltransferase. Post-translational maturation of Notch	Poglut	B	500	85	46	[16, 72]
Modifier	Protein O-fucosyltransferase 1. Post-translational maturation of Notch	POFUT1	K	191	5	1	[16, 72]
Modifier	beta-1,3-N-acetylglucosaminyltransferase radical fringe/ Lfng (lunatic) or Rfng (Radical). Post-translational maturation of Notch	Fringe	K	85	4	3	[16]
Repressor	SHARP/ spen family transcriptional repressor/ Mint/Sharp/SPEN, NCoR/SMRT, KyoT2. Co-repressor of RBP-J	MINT	B	95	1	3	[16, 72]
Repressor	Histone deacetylase 1. Co-repressor of RBP-J	HDAC1	K	220	1	0	[72]
Repressor	Nuclear receptor corepressor. Co-repressor of RBP-J	NCoR	B	77	2	0	[16, 72]
Repressor	Co-repressor interacting with RBP-J	CIR1	B	53	2	1	[16, 72]