Table 3.
Hematologic adverse events
| Any, N (%) | Grade ≥ 3, N (%) | |
|---|---|---|
| DARA-DCEP cycle 1 (N = 31) | ||
| Thrombocytopenia | 8 (25.8) | 5 (16.1) |
| Lymphopenia | 7 (22.6) | 2 (6.5) |
| Neutropenia | 6 (19.4) | 4 (12.9) |
| Documented infection | 2 (6.5) | NA |
| DARA-DCEP cycle 2 (N = 29) | ||
| Thrombocytopenia | 8 (27.6) | 5 (17.2) |
| Lymphopenia | 5 (17.2) | 4 (13.8) |
| Neutropenia | 6 (20.7) | 4 (13.8) |
| Documented infection | 6 (20.7) | NA |
| DARA-DCEP cycle 3 (N = 25) | ||
| Thrombocytopenia | 12 (48.0) | 9 (36.0) |
| Lymphopenia | 9 (36.0) | 5 (20.0) |
| Neutropenia | 6 (24.0) | 2 (8.0) |
| Documented infection | 2 (8.0) | NA |
| DARA maintenance cycle 1 (N = 19) | ||
| Thrombocytopenia | 4 (21.1) | 4 (21.1) |
| Lymphopenia | 2 (10.5) | 1 (5.3) |
| Neutropenia | 0 | 0 |
| Documented infection | 1 (5.3) | NA |
| DARA maintenance cycle 2 (N = 14) | ||
| Thrombocytopenia | 0 | 0 |
| Lymphopenia | 1 (7.1) | 1 (7.1) |
| Neutropenia | 0 | 0 |
| Documented infection | 0 | NA |
| DARA maintenance cycle 3 (N = 11) | ||
| Thrombocytopenia | 1 (9.1) | 1 (9.1) |
| Lymphopenia | 1 (9.1) | 1 (9.1) |
| Neutropenia | 1 (9.1) | 1 (9.1) |
| Documented infection | 0 | NA |
| DARA maintenance cycle 4 (N = 9) | ||
| Thrombocytopenia | 0 | 0 |
| Lymphopenia | 0 | 0 |
| Neutropenia | 2 (22.2) | 0 |
| Documented infection | 0 | NA |
| DARA maintenance cycle 5 (N = 7) | ||
| Thrombocytopenia | 1 (14.3) | 0 |
| Lymphopenia | 0 | 0 |
| Neutropenia | 0 | 0 |
| Documented infection | 0 | NA |
NA not applicable