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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Acta Biomater. 2022 May 9;146:10–22. doi: 10.1016/j.actbio.2022.04.046

Fig. 1.

Fig. 1.

Key examples of various DNA nanostructure designs. (A) DNA tetrahedron [35]. (B) Three-dimensional wireframe rabbit-shaped DNA structure designed from a polygonal mesh architecture [36]. (C) Two-dimensional DNA origami in the shape of a smiley face [38]. (D) Three-dimensional DNA origami vase structure featuring complex curvature [39]. (E) Modular DNA structures composed of 32-nucleotide “brick” motifs [41]. (F) Single-stranded DNA “tiles” acts as pixels in a two-dimensional array [187]. (G) A DNA box designed to be opened via toehold strand displacement to release a cargo of interest [44]. (H) pH-sensitive DNA i-motifs allow the assembly and disassembly of a DNA tetrahedral structure [45]. (I) Heteromultimeric assembly of complex DNA architectures via shape complementarity [46]. J) Homomultimeric assembly of DNA barrel structures into a hollow DNA tube via sticky end adhesion [47].