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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Acta Biomater. 2022 May 9;146:10–22. doi: 10.1016/j.actbio.2022.04.046

Fig. 3.

Fig. 3.

DNA nanostructures for biological applications. (A) BSA modified with positively charged dendrimers to adhere to a 60-helix bundle (60HB) nanostructure enables enhanced nanostructure stability, uptake, and immunoquiescence [68]. (B) Oligolysine-based peptide coating featuring two functional aurein 1.2 sequences that exhibits endosomal escape of the coated DNA nanostructure (EE-DN) in the absence of serum proteins [76]. (C) Cholesterol-bearing 6-helix bundle DNA nanostructures facilitate targeted uptake in white blood cells compared to red blood cells [188]. (D) A DNA origami sheet bearing MUC1-targeted aptamers capable of targeted intracellular delivery of active RNase A [189].