Table 1.
RAS allosteric compounds.
| Year | PDB | Class | Compound Name |
|---|---|---|---|
| 2012 | 4EPY | SW1/2 | 13 |
| 2013 | 4M22 | SW2 | 16 |
| 2013 | 2LWI | SW1/2 | Kobe2601 |
| 2013 | 5ZC6 | SW1/2 | KBFM123 |
| 2014 | 4NMM | G | SML-8-73-1 |
| 2014 | 4PZZ | SW1/2 | 3 |
| 2016 | 5F2E | SW2 | ARS-853 |
| 2017 | 5MLA | G | darpin K55 |
| 2017 | 5V9O | SW2 | 3_AM |
| 2018 | 6F76 | SW1/2 | 3344 |
| 2018 | 6FA4 | SW1/2 | Abd-7 |
| 2018 | 5V9U | SW2 | ARS1620 |
| 2018 | 6N2K | SW2 | 12 |
| 2019 | 6QUV | SW1/2 | 15R |
| 2019 | 6GQY | SW1/2 | CH-3 |
| 2019 | 6V5L | SW1/2 | E22 |
| 2019 | 6GJ8 | SW1/2 | BI 2852 |
| 2019 | 6P8Z | SW2 | 1 |
| 2019 | 6OIM | SW2 | AMG 510* |
| 2020 | 6TAM | SW2 | 3 |
| 2020 | 6UT0 | SW2 | MRTX849 |
*
Approved.