Table 3.
List of RAS superfamily proteins with potentially accessible cysteines in the allosteric pocket.
| Position on KRAS |
Color | RAS superfamily | |
|---|---|---|---|
| G pocket | 12, 14 | red | RabL5 RhoA RhoB RhoC RhoD Rif Rnd1 Rnd2 Rnd3 SRPRB |
| 31 | green | Rab14 Rab39A | |
| 18 | blue | Cdc42 Rab10 Rab13 Rab14 Rab15 Rab1A Rab1B Rab26 Rab2A Rab2B Rab30 Rab33A Rab33B Rab34 Rab37 Rab39A Rab39B Rab41 Rab4A Rab4B Rab8A Rab8B Rac1 Rac2 Rac3 RhoA RhoB RhoC RhoG TC10 TCL |
|
| 145-147 | orange | Arf1 Arf3 Arf4 Arf5 Arf6 Arl10B Arl10C Arl11 Arl4 Arl5 Arl7 Arl8 FLJ22595 Rab15 RabL3 Rerg Ris/RasL12 | |
| 118 | cyan | Di-Ras1 Di-Ras2 E-Ras H-Ras K-Ras2B NKIRas2 N-Ras Rab10 Rab13 Rab1A Rab22A Rab22B Rab32 Rab33A Rab33B Rab38 Rab39A Rab39B Rab3A Rab3B Rab3C Rab3D Rab7L1 Rab8A Rab8B Rap1A Rap1B | |
| SI/SII Pocket | 71, 75 | red | E-Ras Gem NKIRas2 Rad RasL11A RasL11B Rem1 Rnd1 Wrch-1 Wrch-2 |
| 5, 41, 54 | green | ArfRP1 Noey2 | |
| SII-Pocket | 12 | red | RabL5 SRPRB |
| 65, 68 | green | FLJ22595 Rab17 Rab34 Rab36 Rab40A RasL10B | |
| 99 | blue | Rab33A Rab33B RabL5 |