Table 4.

List of kinase proteins with potentially accessible cysteines in the allosteric pocket.

Pocket	Position	Color	Kinases
PIF	Position on PDPK1 148, 150, 155, 157	red	BIKE caMLCK CDC7 CDK4 CDK6 CK1d CK1e CLIK1 CLIK1L HIPK1 HIPK2 HIPK3 ILK IRAK1 KIS KSR2 LMR1 MAP2K4 MAP3K1 MAP3K2 MAP3K3 MAPKAPK3 PKCa PKCb PKCe PKCh PKCi PKCz PKN1 PKN2 PKN3 PKR SgK495 TAO1 TAO2 TAO3 TTBK1 TTBK2 TYK2
	115, 118	green	AXL CLIK1 CLIK1L CTK FAK MPSK1 STLK3 STLK5 STLK6 TYK2 ULK4 YANK1 YANK2 YANK3
	124, 127, 128	blue	AAK1 BIKE CDK11 CDK8 DRAK1 DRAK2 EphA7 Erk1 Erk2 HH498 IKKb MAPKAPK2 NEK6 NEK7 PSKH1 PSKH2 SgK071 SgK494 TEC TLK1 TLK2
Myristic	Position on ABL1 356, 359, 360, 363	red	AAK1 ACTR2 ACTR2B ALK2 BMPR2 BMX BTK CCK4 CHK2 EGFR ErbB2 ErbB4 Erk1 Erk2 GAK GCK HPK1 IRAK2 IRAK4 ITK KHS1 LKB1 LOK MAP3K19 MINK MOS MUSK NRBP1 NRBP2 NRK p70S6K p70S6Kb PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDK1 PEK PKACg PKCd PKG2 RIPK3 ROS SLK smMLCK SRPK2 TAK1 TBCK TEC TNIK TXK Wnk1 Wnk2 Wnk3
	448, 452	green	AAK1 AKT1 AMPKa1 AMPKa2 AurA AurB AurC BIKE CaMK1d CHK2 CYGD FAK GAK HH498 IKKa IKKb LIMK1 LIMK2 MAPKAPK2 MAPKAPK5 MASTL MRCKa MRCKb NEK1 NEK11 NEK2 NEK3 NEK4 NEK5 NIK NRBP1 NRBP2 PIM3 QIK QSK SIK smMLCK SNRK TAO1 TAO2 TAO3 TBCK TESK1 TLK1 TLK2 TSSK1 TSSK2 ULK1 ULK2 VRK1 VRK3 Wnk1 Wnk2 Wnk3 Wnk4
	482, 483	blue	ABL1 ABL2 ACK ARAF AXL BLK BRK CCK4 COT CSK CTK DDR1 DDR2 DYRK2 DYRK3 EGFR EphA1 EphA10 EphA2 EphA3 EphA4 EphA5 EphA7 EphA8 EphB1 EphB2 EphB3 EphB4 EphB6 ErbB2 ErbB3 ErbB4 FAK FER FES FGFR1 FGFR2 FGFR3 FGFR4 FGR FRK FYN HCK IGF1R IRR JAK1 JAK2 JAK3 LCK LIMK1 LKB1 LTK LYN MER MET MLKL MUSK NIK RET RIPK1 RON ROR1 ROR2 ROS RSKL1 RYK SRC SRM SuRTK106 SYK TESK1 TESK2 TIE1 TIE2 TRKA TRKB TRKC TYRO3 YES ZAP70
Type III	Position on IGF-1R 1046, 1050	red	EphA7 Erk1 Erk2 RYK SgK494 TEC
	1054, 1063-1065	green	BARK1 BARK2 CaMK2a CaMK2b CaMK2d CaMK2g CASK CDC7 EGFR IRAK2 LMR1 LMR3 LTK MAP2K7 MAPKAPK3 MELK MER NIK ROR1 ROR2 RSKL1 smMLCK TBCK TTBK2 TYRO3 VRK3
	1134	blue	DYRK1A DYRK1B DYRK2 DYRK3 DYRK4 LRRK1 PKD1 PKD2 PKD3 ULK4
	1152	orange	AAK1 BIKE CDKL1 CDKL2 CDKL3 CDKL4 CDKL5 Erk1 Erk2 Erk7 FLT1 FLT4 Fused GAK KDR KIT KSR1 KSR2 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPKAPK5 MNK1 MNK2 NIK PBK PDGFRb PKD1 PKD2 PKD3 PRP4 SuRTK106 TAK1 TGFbR2 ZAK
	1173, 1174	cyan	AKT1 AurA AurB AurC BUB1 CaMK1g DCAMKL3 MAST1 MAST2 MAST3 MAST4 MASTL MSK1 MSK2 PKCb PKCe PKG1 PLK3 RSK2 STK33
IV-C1	Position on CHK1 93, 96, 97, 99	red	AurB BMPR2 CaMK2a CaMK2b CaMK2d CaMK2g CASK CDKL3 DRAK1 DRAK2 JNK1 JNK2 JNK3 MAST1 MISR2 MYT1 PEK PFTAIRE1 PKR
	133	green	AurB BMPR2 CaMK2a CaMK2b CaMK2d CaMK2g CASK CDKL3 CHED CRK7 DRAK1 DRAK2 JNK1 JNK2 JNK3 MAST1 MISR2 MYT1 NRBP1 PEK PFTAIRE1 PKR SSTK TSSK1 TSSK2 TSSK3 Wnk1 Wnk2 Wnk3 Wnk4
	200, 204-206, 209	blue	BUB1 CaMKK1 CaMKK2 CASK CDK11 CDK4 CDK8 GCN2 IRAK3 JNK2 MAP3K1 MAST1 MAST2 MAST3 MAST4 NIK PKN3 SBK SgK069 SgK071 SgK110 SSTK Wee1
IV-C2	Position on MAPK14 195-197	red	CaMK4 CDC7 CDK2 COT HGK LOK MINK MYO3A MYO3B NRK PHKg1 PHKg2 SgK069 SLK TNIK ULK3
	232	green	BMPR1A BMPR1B FLT1 KDR MAP2K5 PLK2 RIPK1 TRKA TRKC
	249, 252	blue	Erk1 Erk2 HIPK4 IRE1 PKG2
	291, 292291-292	orange	CDK5 DMPK2 HH498 LATS2 MSK2 NDR1 NEK6 PFTAIRE1 PKN3 Wnk2
IV-C3	Position on MAPK8 197, 199	red	FLT1 JAK3 KDR MAP2K5 NEK6 NEK7 NEK9
	231, 234	green	CaMK4 CDC7 CDK2 COT HGK KIT LOK MINK MYO3A MYO3B NEK1 NEK5 NEK8 NEK9 NRK PHKg1 PHKg2 SBK SgK069 SgK110 SLK TNIK