Fig. 2.

The heatmap represents the relative value of each serum metabolite in the MHNW → MUNW, MHO → MHO, and MHO → MUO groups in comparison to that in the MHNW → MHNW group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 compared with MHNW → MHNW participants. MHNW, metabolically healthy normal weight; MUNW, metabolically unhealthy normal weight; MHO, metabolically healthy overweight/obesity; MUO, metabolically unhealthy overweight/obesity; MHNW→MHNW, remaining in MHNW; MHNW→MUNW, MHNW transition to MUNW; MHO→MHO, remaining in MHO; MHO→MUO, MHO transition to MUO; VLDL-PN, very low-density lipoprotein particle numbers; VLDL-CH, very low-density lipoprotein cholesterol; VLDL-CE, very low-density lipoprotein cholesteryl ester; VLDL-FC, very low-density lipoprotein free cholesterol; VLDL-AB, very low-density lipoprotein apolipoprotein B-100; VLDL-PL, very low-density lipoprotein phospholipid; VLDL-TG, very low-density lipoprotein triglycerides; IDL-PN, intermediate-density lipoprotein particle numbers; IDL-CH, intermediate-density lipoprotein cholesterol; IDL-CE, intermediate-density lipoprotein cholesteryl ester; IDL-FC, intermediate-density lipoprotein free cholesterol; IDL-AB, intermediate-density lipoprotein apolipoprotein B-100; IDL-PL, intermediate-density lipoprotein phospholipid; IDL-TG, intermediate-density lipoprotein triglyceride; HDL-CH, high-density lipoprotein cholesterol; HDL-CE, high-density lipoprotein cholesteryl ester; HDL-FC, high-density lipoprotein free cholesterol; HDL-PL, high-density lipoprotein phospholipid; HDL-TG, high-density lipoprotein triglycerides; AA, amino acid; VLDL1-CH, very low-density lipoprotein-1 cholesterol; VLDL1-CE, very low-density lipoprotein-1 cholesteryl ester; VLDL1-FC, very low-density lipoprotein-1 free cholesterol; VLDL1-PL, very low-density lipoprotein-1 phospholipid; VLDL1-TG, very low-density lipoprotein-1 triglycerides; VLDL2-CH, very low-density lipoprotein-2 cholesterol; VLDL2-CE, very low-density lipoprotein-2 cholesteryl ester; VLDL2-FC, very low-density lipoprotein-2 free cholesterol; VLDL2-PL, very low-density lipoprotein-2 phospholipid; VLDL2-TG, very low-density lipoprotein-2 triglycerides; VLDL3-CH, very low-density lipoprotein-3 cholesterol; VLDL3-CE, very low-density lipoprotein-3 cholesteryl ester; VLDL3-FC, very low-density lipoprotein-3 free cholesterol; VLDL3-PL, very low-density lipoprotein-3 phospholipid; VLDL3-TG, very low-density lipoprotein-3 triglycerides; VLDL4-CH, very low-density lipoprotein-4 cholesterol; VLDL4-CE, very low-density lipoprotein-4 cholesteryl ester; VLDL4-FC, very low-density lipoprotein-4 free cholesterol; VLDL4-PL, very low-density lipoprotein-4 phospholipid; VLDL4-TG, very low-density lipoprotein-4 triglycerides; VLDL5-CH, very low-density lipoprotein-5 cholesterol; VLDL5-CE, very low-density lipoprotein-5 cholesteryl ester; VLDL5-FC, very low-density lipoprotein-5 free cholesterol; VLDL5-PL, very low-density lipoprotein-5 phospholipid; VLDL5-TG, very low-density lipoprotein-5 triglycerides