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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Cell Signal. 2018 Oct 19;53:234–245. doi: 10.1016/j.cellsig.2018.10.011

Fig. 4.

Fig. 4.

Several DUSPs are induced in preadipocytes and adipocytes in response to TNFα. Total RNA was harvested over time from preadipocytes (closed circles) and adipocytes (open circles) stimulated concurrently with TNFα (100 pM). DUSP mRNA expression was assessed by qRT-PCR. DUSPs were grouped as: nuclear (gp1), cytosolic ERK-specific (gp2), and DUSPs that selectively dephosphorylate stress activated MAPKs (gp3). All data were normalized to 18S rRNA and expressed relative to untreated cells. Genes were selected as ‘inducible’ when upregulated above a 2-fold criterion indicated by the dashed line, while genes were considered suppressed that fell below a 0.5 criterion indicated by the dotted line on the graph.