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Working model for a role of DUSPs in adipocytes during inflammatory stress. Working model illustrating a role for Dusp1, Dusp8 and Dusp16 in modulating the magnitude and duration of MAPK signaling in response to TNFα stimulation in adipocytes. While Dusp8 was shown to be downstream of MAPK signaling, Dusp1 and Dusp16 were induced by MAPK-independent mechanisms (dotted line).
