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. Author manuscript; available in PMC: 2022 Oct 24.
Published in final edited form as: Chem Biol Drug Des. 2020 Mar 13;95(6):584–599. doi: 10.1111/cbdd.13671

Figure 8: Effects of compounds VS4 and VS14 on cell invasion.

Figure 8:

(A) Transwell invasion assays of HER2/3-transformed FAK +/+ MEFs treated with 10 μM defactinib, VS4, VS14, or negative control. HRG (20 ng/mL) was added in the lower chamber for chemotaxis and invaded cells were stained with crystal violet. Defactinib treatment reduced invasion however VS14 was more effective. Compound VS4 and the negative control had limited effect on invasion. Quantitation represents averaged results from six fields of view in triplicate. Error bars represent standard deviations from the mean. One-way ANOVA statistics were performed (* denotes p < 0.05 compared to DMSO, and # denotes p < 0.05 compared to defactinib). (B) Representative images from experiment in (A).