Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding affinity and relative potency to reverse morphine-induced analgesia of representative NPFF peptidic analogues.77
| Compound | Binding affinity Ki (nM)a | Minimal effective dose (nmol)b |
|---|---|---|
| NPFF | 0.21 ± 0.03 | 22 |
| [Tyr1]NPFF | 0.20 ± 0.04 | 8.8 |
| [Gly5]NPFF | 1.2 ± 0.2 | 8.8 |
Affinity for rat spinal cord membranes using [125I][Tyr1]NPFF tracer.
Mimimal effective dose (i.c.v.) able to significantly reverse morphine-induced analgesia.
