FIGURE 1.

Sensitivity of tissue factor (TF)-initiated thrombin generation to factor XI (FXI). A–D, Thrombin generation in FXI-depleted plasma (FXI-dep) supplemented with 30 nM FXI or vehicle was initiated by the addition of TF (0.125–1 pM) and Ca²⁺. Experiments were run in the presence or absence of the anti-FXI mAb, 1A6 (30 μg/ml). E, Endogenous thrombin generation potential (ETP), (F) peak thrombin concentrations, (G) lag time, and (H) peak time were estimated from the thrombin generation curves for each condition. Data are means ± standard error of the mean (n = 3). *P < .05 with respect to FXI-dep+FXI