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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: J Thromb Haemost. 2022 Apr 8;20(6):1350–1363. doi: 10.1111/jth.15716

FIGURE 2.

FIGURE 2

Sensitivity of activated factor X (FXa)-initiated thrombin generation to factor XI (FXI). A–B, FXa (0.1 or 0.5 nM) was used to initiate thrombin generation in FXI-depleted plasma (FXI-dep) supplemented with 30 nM FXI or vehicle in the presence or absence of the anti-FXI mAb, 1A6 (30 μg/ml). C, Endogenous thrombin generation potential (ETP), (D) peak thrombin concentration, (E) lag time, and (F) peak time were estimated from the thrombin generation curves recorded for each condition. Data are means ± standard error of the mean (n = 3). *P < .05 with respect to FXI-dep+FXI