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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: J Thromb Haemost. 2022 Apr 8;20(6):1350–1363. doi: 10.1111/jth.15716

FIGURE 6.

FIGURE 6

Extended Hockin-Mann model. Reactions in the extended (ext.) HM model that describes the TF pathway of thrombin generation. Arrows with asterisks (*) indicate reactions that are added to the original HM model. ATIII, antithrombin; C1-INH, C1 inhibitor; FII, prothrombin; FIX, coagulation factor IX; FV, coagulation factor V; FVII, coagulation factor VII; FVIII, coagulation factor VIII; FVIIIa1 and FVIIIa2, trimeric forms of FVIIIa; FX, coagulation factor X; FXI, coagulation factor XI; HM, Hockin–Mann model; mFIIa, meizothrombin; TF, tissue factor; TFPI, tissue factor pathway inhibitor; the activated forms of the coagulation factor are represented with “a” added as the suffix, such as FIIa, FVIIa, FVIIIa, FIXa, FXa, and FVa