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. 2022 Oct 24;17(10):e0276649. doi: 10.1371/journal.pone.0276649

Fig 3. Circulating risk variant APOL1 and pathological changes.

Fig 3

(A) Circulating APOL1 protein localizes to injured kidneys. To induce kidney damage and proteinuria in Alb/APOL1 mice (Alb-G0, Alb-G1, and Alb-G2) and their non-transgenic littermate controls (Lit. Cont.), mice received interferon-γ, puromycin, and basic fibroblast growth factor. Immunohistochemical detection of APOL1 protein in kidney from Alb/APOL1 mice after kidney-damaging intervention is shown compared with their littermate controls and non-treated control animals. Risk variant APOL1 protein localized to the kidney in Alb/APOL1-G1 mice and to a lesser extent in Alb/APOL1-G2 mice. Scale bars are 25 μm. (B) Circulating risk variant APOL1 is associated with pathological changes in the triple intervention model. Hematoxylin and eosin staining of kidney from Alb/APOL1 mice with and without the triple intervention demonstrated pathological differences in kidneys from treated mice that have circulating APOL1-G1 and APOL1-G2. Scale bars are 50 μm.