Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 10;13:991928. doi: 10.3389/fimmu.2022.991928

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Tan, Sugata, Ono and Satou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Role of HBZ in immune evasion of infected cells. HBZ induces expression of co-inhibitory molecules to suppress immune activation and confers anti-apoptotic properties by altering expression pattern of pro- and anti-apoptotic proteins. HBZ also induces IL-10 expression in infected cells and antigen presenting cells through TIGIT. IL-10 acts to suppress host immune response as well as enhancing cellular proliferation of infected cells through modulation of STAT signaling by HBZ (not shown).