Table II.
Studies exploring the expression and clinical significance of CRY genes in patients with CRC.
| Author, year | Gene | Expression in CRC | Observations | (Refs.) |
|---|---|---|---|---|
| Hasakova, 2018 | Cry1 | Upregulated | High expression of Cry1 was associated with unfavorable survival in females. Higher expression of Cry1 in the right-sided colon tumor tissue tended to be associated with unfavorable survival in females | (50) |
| He, 2022 | Cry1 | Upregulated | Not mentioned | (37) |
| Yu, 2013 | Cry1 | Upregulated | High Cry1 expression was associated with lymph node metastasis and TNM stage III-IV and tended to be associated with poor OS in patients with CRC | (73) |
| Aroca-Siendones, 2021 | Cry1 | Not mentioned | High expression of Cry1 was associated with lower OS and DFS at five years in patients with CRC | (49) |
| Lu, 2015 | Cry1 | No differences | Not specified | (46) |
| Mazzoccoli, 2011 | Cry1 | No differences | In patients with CRC, elevated Cry1 expression was associated with poorer survival. Cry1 was particularly decreased in elderly female patients with CRC and in tumors located in the transverse colon tend to exhibit lower Cry expression level. | (39) |
| Lu, 2015 | Cry2 | Not mentioned | Cry2 expression was higher in tissue with pathological complete regression | (46) |
| Hasakova, 2018 | Cry2 | Decreased | Not specified | (50) |
| He, 2022 | Cry2 | Decreased | Patients with CRC with high Cry2 expression had a tendency of unfavorable survival prognosis | (37) |
| Mazzoccoli, 2011 | Cry2 | Decreased | Patients with CRC with high Cry2 expression had an unfavorable survival prognosis | (39) |
CRC, colorectal cancer; Cry1, cryptochrome 1; OS, overall survival; DFS, disease-free survival.