Table 3:
Transition zone – results of the logistic regression analysis with the area under the curve (AUC), sensitivity and specificity values demonstrating the capabilities of individual metric and combinations of parameters (listed in order of significance ) to discriminate tissues of interest.
| Parameter | Benign/All Cancers | ≤G3+3/≥G3+4 | ≤G3+4/≥G4+3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | AUC | Sensitivity | Specificity | |
| T2-weighted | 0.77 | 58.3 | 87.5 | 0.57 | 66.7 | 53.3 | 0.54 | 36.4 | 88.9 |
| ADC | 0.91 | 69.4 | 100.0 | 0.74 | 72.2 | 73.3 | 0.62 | 81.8 | 55.6 |
| Peak Enhancement (PE) | 0.56 | 58.3 | 58.3 | 0.59 | 44.4 | 80.0 | 0.58 | 45.5 | 77.8 |
| Max Enhancement Slope (ES) | 0.68 | 47.2 | 91.7 | 0.69 | 50.0 | 86.7 | 0.67 | 63.6 | 66.7 |
| Washout Slope (WO) | 0.67 | 97.2 | 37.5 | 0.76 | 77.8 | 73.3 | 0.69 | 68.2 | 77.8 |
| Ktrans | 0.66 | 91.7 | 37.5 | 0.74 | 83.3 | 66.7 | 0.71 | 68.2 | 77.8 |
| kep | 0.66 | 88.6 | 45.8 | 0.68 | 66.7 | 73.3 | 0.70 | 90.9 | 55.6 |
| vl | 0.50 | 38.9 | 70.8 | 0.57 | 83.3 | 40.0 | 0.60 | 63.6 | 66.7 |
| Choline (Cho) | 0.56 | 47.2 | 83.3 | 0.60 | 61.1 | 73.3 | 0.69 | 50.0 | 100 |
| Citrate (Cit) | 0.80 | 75.0 | 75.0 | 0.61 | 50.0 | 93.3 | 0.64 | 40.9 | 100 |
| Creatine (Cre) | 0.77 | 61.1 | 87.5 | 0.65 | 61.1 | 73.3 | 0.70 | 54.6 | 88.9 |
| Choline/Citrate (CC) | 0.94 | 94.4 | 91.7 | 0.40 | 22.2 | 93.3 | 0.55 | 59.1 | 66.7 |
| [Choline+Creatine]/Citrate (CCC) | 0.89 | 77.8 | 91.7 | 0.46 | 22.2 | 100.0 | 0.55 | 27.3 | 100.0 |
| Choline/Creatine (Cho/Cre) | 0.97 | 86.1 | 95.8 | 0.73 | 72.2 | 86.7 | 0.55 | 40.9 | 77.8 |
|
| |||||||||
| Combined (Cho/Cre, ADC) | 0.99 | 100 | 91.7 | ||||||
| Combined (WO, ADC, Cre) | 0.93 | 86.7 | 94.4 | ||||||
| Combined (Cho, WO) | 0.92 | 77.8 | 100 | ||||||