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. 2022 Oct 21;55:e0240-2022. doi: 10.1590/0037-8682-0240-2022

TABLE 2: Characteristics of T. cruzi-HIV coinfection according to death status (survivors vs deceased).

Variables Median (IQR) or n (%) p-value (deceased vs survivors)
Survivors (n=5) Deceased (n=6)
Age at coinfection diagnosis, years 64 (48-66) 50.5 (46-58) 0.21
Sex
Men 3 (60.0) 1 (16.7) 0.24
Women 2 (40.0) 5 (83.3)
Race
White 1 (20.0) 4 (66.7) 0.24
Mixed 4 (80.0) 1 (16.7) 0.08
Black 0 (0.0) 1 (16.7) 1.00
Educational level
Illiterate 2 (40.0) 2 (33.3) 1.00
<9 years 2 (40.0) 4 (66.7) 0.57
>9 years 1 (20.0) 0 (0.0) 0.46
CD transmission mode
Vectorial 5 (100.0) 6 (100.0) 1.00
Time away from an endemic area
None 0 (0.0) 1 (16.7) 1.00
1-20 years 2 (40.0) 0 (0.0) 0.18
>20 years 3 (60.0) 5 (83.3) 0.55
Non-endemic area 0 (0.0) 0 (0.0) 1.00
HIV transmission mode
Unprotected heterosexual contact 3 (60.0) 5 (83.3) 0.54
Unprotected homosexual contact 1 (20.0) 1 (16.7) 1.00
Contaminated objects 1 (20.0) 0 (0.0) 0.46
Antiretroviral therapy (n=10)
No 0 (0.0) 2 (33.3) 0.47
Yes 4 (100.0) 4 (66.7)
CD4+ at HIV diagnosis 448.5 (133-831), n=4 350 (198-396.5), n=4 0.56
Viral load at HIV diagnosis 12500 (0-42051.5), n=4 1500 (399-300000), n=3 0.48
CD4+ <200 at coinfection diagnosis (n=8)
No 3 (75.0) 3 (75.0) 1.00
Yes 1 (25.0) 1 (25.0)
Time of coinfection diagnosis
Before 1997 0 (0.0) 2 (33.3) 0.46
After 1997 5 (100.0) 4 (66.7)
CD clinical form at coinfection diagnosis
Indeterminate 1 (20.0) 1 (16.7) 1.00
Cardiac 2 (40.0) 4 (66.7) 0.57
Digestive 1 (20.0) 1 (16.7) 1.00
Cardio-digestive 1 (20.0) 0 (0.0) 0.45
Classification of cardiac form at coinfection diagnosis (n=7)
Stage A 0 (0.0) 2 (50.0) 0.43
Stage B1 1 (33.3) 1 (25.0) 1.00
Stage B2 1 (33.3) 1 (25.0) 1.00
Stage C 1 (33.3) 0 (0.0) 0.43
Classification of digestive form at coinfection diagnosis (n=3)
Megaesophagus 0 (0.0) 1 (100.0) 0.33
Megacolon 0 (0.0) 0 (0.0) 1.00
Megaesophagus and megacolon 2 (100.0) 0 (0.0) 0.33
Qualitative xenodiagnosis at coinfection diagnosis (n=4)
Negative 0 (0.0) 0 (0.0) ---*
Positive 0 (0.0) 4 (100.0)
Quantitative xenodiagnosis at coinfection diagnosis (n=4) --- 16.3 (5-55.0) ---
Diagnosis of CD or HIV
CD first 2 (40.0) 4 (66.7) 0.57
HIV first 3 (60.0) 2 (33.3)
Comorbidities at coinfection diagnosis
Arterial hypertension 3 (60.0) 3 (50.0) 1.00
Diabetes mellitus 0 (0.0) 0 (0.0) ---*
Dyslipidemia 3 (60.0) 2 (33.3) 0.57
Hepatitis B 0 (0.0) 1 (16.7) 1.00
Non-Chagasic cardiomyopathy 0 (0.0) 0 (0.0) ---*
Antiparasitic drugs
No 4 (80.0) 1 (16.7) 0.08
Yes 1 (20.0) 5 (83.3)
High parasitemia under risk of reactivation (n=5)
No 0 (0.0) 3 (60.0) ---*
Yes 0 (0.0) 2 (40.0)
Clinical reactivation of CD
No 5 (100.0) 5 (83.3) 1.00
Yes 0 (0.0) 1 (16.7)

* p-value not calculated due to a lack of cases in the exposure or outcome categories.