TABLE 2: Characteristics of T. cruzi-HIV coinfection according to death status (survivors vs deceased).
Variables | Median (IQR) or n (%) | p-value (deceased vs survivors) | |
---|---|---|---|
Survivors (n=5) | Deceased (n=6) | ||
Age at coinfection diagnosis, years | 64 (48-66) | 50.5 (46-58) | 0.21 |
Sex | |||
Men | 3 (60.0) | 1 (16.7) | 0.24 |
Women | 2 (40.0) | 5 (83.3) | |
Race | |||
White | 1 (20.0) | 4 (66.7) | 0.24 |
Mixed | 4 (80.0) | 1 (16.7) | 0.08 |
Black | 0 (0.0) | 1 (16.7) | 1.00 |
Educational level | |||
Illiterate | 2 (40.0) | 2 (33.3) | 1.00 |
<9 years | 2 (40.0) | 4 (66.7) | 0.57 |
>9 years | 1 (20.0) | 0 (0.0) | 0.46 |
CD transmission mode | |||
Vectorial | 5 (100.0) | 6 (100.0) | 1.00 |
Time away from an endemic area | |||
None | 0 (0.0) | 1 (16.7) | 1.00 |
1-20 years | 2 (40.0) | 0 (0.0) | 0.18 |
>20 years | 3 (60.0) | 5 (83.3) | 0.55 |
Non-endemic area | 0 (0.0) | 0 (0.0) | 1.00 |
HIV transmission mode | |||
Unprotected heterosexual contact | 3 (60.0) | 5 (83.3) | 0.54 |
Unprotected homosexual contact | 1 (20.0) | 1 (16.7) | 1.00 |
Contaminated objects | 1 (20.0) | 0 (0.0) | 0.46 |
Antiretroviral therapy (n=10) | |||
No | 0 (0.0) | 2 (33.3) | 0.47 |
Yes | 4 (100.0) | 4 (66.7) | |
CD4+ at HIV diagnosis | 448.5 (133-831), n=4 | 350 (198-396.5), n=4 | 0.56 |
Viral load at HIV diagnosis | 12500 (0-42051.5), n=4 | 1500 (399-300000), n=3 | 0.48 |
CD4+ <200 at coinfection diagnosis (n=8) | |||
No | 3 (75.0) | 3 (75.0) | 1.00 |
Yes | 1 (25.0) | 1 (25.0) | |
Time of coinfection diagnosis | |||
Before 1997 | 0 (0.0) | 2 (33.3) | 0.46 |
After 1997 | 5 (100.0) | 4 (66.7) | |
CD clinical form at coinfection diagnosis | |||
Indeterminate | 1 (20.0) | 1 (16.7) | 1.00 |
Cardiac | 2 (40.0) | 4 (66.7) | 0.57 |
Digestive | 1 (20.0) | 1 (16.7) | 1.00 |
Cardio-digestive | 1 (20.0) | 0 (0.0) | 0.45 |
Classification of cardiac form at coinfection diagnosis (n=7) | |||
Stage A | 0 (0.0) | 2 (50.0) | 0.43 |
Stage B1 | 1 (33.3) | 1 (25.0) | 1.00 |
Stage B2 | 1 (33.3) | 1 (25.0) | 1.00 |
Stage C | 1 (33.3) | 0 (0.0) | 0.43 |
Classification of digestive form at coinfection diagnosis (n=3) | |||
Megaesophagus | 0 (0.0) | 1 (100.0) | 0.33 |
Megacolon | 0 (0.0) | 0 (0.0) | 1.00 |
Megaesophagus and megacolon | 2 (100.0) | 0 (0.0) | 0.33 |
Qualitative xenodiagnosis at coinfection diagnosis (n=4) | |||
Negative | 0 (0.0) | 0 (0.0) | ---* |
Positive | 0 (0.0) | 4 (100.0) | |
Quantitative xenodiagnosis at coinfection diagnosis (n=4) | --- | 16.3 (5-55.0) | --- |
Diagnosis of CD or HIV | |||
CD first | 2 (40.0) | 4 (66.7) | 0.57 |
HIV first | 3 (60.0) | 2 (33.3) | |
Comorbidities at coinfection diagnosis | |||
Arterial hypertension | 3 (60.0) | 3 (50.0) | 1.00 |
Diabetes mellitus | 0 (0.0) | 0 (0.0) | ---* |
Dyslipidemia | 3 (60.0) | 2 (33.3) | 0.57 |
Hepatitis B | 0 (0.0) | 1 (16.7) | 1.00 |
Non-Chagasic cardiomyopathy | 0 (0.0) | 0 (0.0) | ---* |
Antiparasitic drugs | |||
No | 4 (80.0) | 1 (16.7) | 0.08 |
Yes | 1 (20.0) | 5 (83.3) | |
High parasitemia under risk of reactivation (n=5) | |||
No | 0 (0.0) | 3 (60.0) | ---* |
Yes | 0 (0.0) | 2 (40.0) | |
Clinical reactivation of CD | |||
No | 5 (100.0) | 5 (83.3) | 1.00 |
Yes | 0 (0.0) | 1 (16.7) |
* p-value not calculated due to a lack of cases in the exposure or outcome categories.