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. 2022 Oct 10;12:1004014. doi: 10.3389/fonc.2022.1004014

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Copyright © 2022 Hartal-Benishay, Saadi, Toubiana, Shaked, Lalzar, Abu Hatoum, Tal, Selig and Barki-Harrington

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between MBTPS1 levels and its downstream targets in human CRC. (A) Relative MBTPS1 mRNA levels in tumors compared to normal surrounding tissue obtained from the same patient (n=12 patients). Note that while in some patients the levels of MBTPS1 are unchanged (green circles), in others the levels are markedly elevated (red circles) or markedly reduced (light blue circles). (B–D) Positive correlation between MBTPS1 and three MBTPS1 targets: SREBF1 (r = 0.6963, P = 0.0173), SREBF2 (r = 0.8086, P =0.0083) and ATF6 (r = 0.7526, P = 0.0047). (E, F) No correlation between MBTPS1 and SST (r = -0.5691, P = 0.1078) or CREB3 (r = 0.3443, P = 0.3299). (G) A negative correlation between MBTPS1 and BDNF (r = -0.7138, P = 0.0308).