Table 2.
Baseline characteristics of patients with versus without inhibitors of renin-angiotensin system at discharge.
| Entire cohort (N = 2904) | Propensity-score matched patients (N = 1559) | |||||||
|---|---|---|---|---|---|---|---|---|
| With RASI (N = 2316) |
Without RASI (N = 588) |
SD | P value | With RASI (N = 1003) |
Without RASI (N = 556) |
SD | P value | |
| Age (yrs) | 63.9 ± 12.5 | 66.0 ± 12.7 | 0.172 | <.001 | 65.0 ± 12.4 | 65.5 ± 12.6 | 0.002 | .429 |
| Male | 1708 (73.7) | 422 (71.8) | -0.043 | .347 | 723 (72.1) | 406 (73.0) | 0.032 | .723 |
| Body mass index (kg/m2) | 24.00 ± 3.26 | 23.33 ± 3.21 | -0.208 | <.001 | 23.42 ± 3.01 | 23.43 ± 3.17 | 0.033 | .960 |
| Hypertension | 1133 (48.9) | 271 (46.1) | -0.050 | .230 | 457 (45.6) | 255 (45.9) | 0.007 | .916 |
| Diabetes mellitus | 629 (27.2) | 181 (30.8) | 0.088 | .089 | 292 (29.1) | 168 (30.2) | 0.017 | .643 |
| Prior angina pectoris | 182 (7.9) | 65 (11.1) | 0.100 | .016 | 84 (8.4) | 59 (10.6) | 0.052 | .144 |
| Prior myocardial infarction | 201 (8.7) | 51 (8.7) | 0.003 | 1.000 | 90 (9.0) | 49 (8.8) | <0.001 | 1.000 |
| Prior heart failure | 23 (1.0) | 8 (1.4) | 0.022 | .498 | 14 (1.4) | 7 (1.3) | -0.025 | 1.000 |
| Prior stroke | 156 (6.7) | 43 (7.3) | 0.022 | .648 | 72 (7.2) | 41 (7.4) | -0.010 | .919 |
| Current smoker | 949 (41.0) | 218 (37.1) | -0.082 | .090 | 392 (39.1) | 213 (38.3) | 0.004 | .786 |
| Killip class ≥ II | 520 (22.5) | 140 (23.8) | 0.039 | .508 | 230 (22.9) | 128 (23.0) | -0.011 | 1.000 |
| eGFR < 60 mL/min/1.73 m2 | 406 (17.5) | 140 (23.8) | 0.140 | .001 | 206 (20.5) | 123 (22.1) | 0.009 | .476 |
| Left ventricular EF (%) | 45.6 ± 2.5 | 45.6 ± 2.5 | -0.022 | .679 | 45.5 ± 2.5 | 45.6 ± 2.5 | 0.025 | .613 |
| STEMI | 1445 (62.4) | 330 (56.1) | -0.130 | .006 | 603 (60.1) | 317 (57.0) | -0.031 | .237 |
| Coronary reperfusion* | 2251 (97.2) | 557 (94.7) | -0.114 | .004 | 969 (96.6) | 535 (96.2) | <0.001 | .671 |
| Medications at discharge | ||||||||
| Aspirin | 2313 (99.9) | 586 (99.7) | -0.036 | .268 | 1001 (99.8) | 555 (99.8) | 0.015 | 1.000 |
| P2Y12 inhibitor | 2261 (97.6) | 556 (94.6) | -0.126 | <.001 | 969 (96.6) | 536 (96.4) | 0.016 | .885 |
| Beta-blockers | 2103 (90.8) | 405 (68.9) | -0.471 | <.001 | 800 (79.8) | 399 (71.8) | -0.008 | <.001 |
| Statins | 2195 (94.8) | 527 (89.6) | -0.170 | <.001 | 931 (92.8) | 508 (91.4) | -0.015 | .322 |
Values are mean ± standard deviation or number (%).
BB = beta-blockers, EF = ejection fraction, eGFR = estimated glomerular filtration rate by MDRD equation, RASI = inhibitors of renin-angiotensin system, SD = standardized difference, STEMI = ST elevation myocardial infarction.
*
Includes reperfusion by percutaneous coronary intervention, thrombolysis, coronary artery bypass graft, myocardial bridge, or myocardial infarction with non-obstructed coronary arteries (MINOCA).