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. 2022 Oct 10;13:1007737. doi: 10.3389/fimmu.2022.1007737

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Copyright © 2022 Wan, Zhang, Jia, Qin, Sun, Xin, Zeng, Jing, Fang, Pan, Zeng, Bai, Wang, Ma and Ni

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GO and KEGG Pathway enrichment analysis of target genes of differentially expressed miRNAs According to the enrichment results of Go, and the degree of enrichment is measured by rich factor, FDR value and the number of miRNA target genes enriched on this Go term and pathway. The larger the rich factor, the greater the degree of enrichment. The general value range of FDR is 0-1. The closer it is to zero, the more significant the enrichment is. (A–C) The GO analysis. (D–F) The KEGG Pathway enrichment analysis. The horizontal axis is rich factor, which refers to the ratio of the number of differential miRNA target genes enriched into GO term or pathway to the number of differential miRNA target genes annotated, with a larger value indicating more significant enrichment. The vertical axis is GO term or pathway.