Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 24;13:6321. doi: 10.1038/s41467-022-34036-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Schematic illustration of the implantation of the cell patch for the treatment of inoperable ovarian cancer and the representative image of the lyophilized hydrogel patch loaded with EI-NP. Scale bar: 5 mm. b Representative bioluminescence images of the mice bearing ID8-Luc ovarian tumors after different treatments of PBS, aPD-1, VNP@Gel, GD/EI-NP@Gel, VNP-GD@Gel, VNP-GD/EI-NP@Gel, VNP-GD/EI-NP@Gel+aPD-1 and VNP-GD/EI-NP@Patch+aPD1 (n = 6 mice). c Data analysis of the normalized intensity of the bioluminescence signals of the mice with different treatments. Data are presented as mean ± s.d. (n = 6 mice) and analyzed with two-way ANOVA followed by Tukey’s multiple comparisons test. VNP-GD/EI-NP@Patch+aPD1 vs. VNP-GD/EI-NP@Gel: **P = 0.0078; VNP-GD/EI-NP@Patch+aPD1 vs. VNP-GD@Gel: ***P = 0.0005. d Survival curve of the ovarian tumor-bearing mice after different treatment of PBS, aPD-1, VNP@Gel (hydrogel loaded with VNP), GD/EI-NP@Gel (GSDMD protein cage, and EI-NP co-loaded in the hydrogel), VNP-GD@Gel (GSDMD protein cage-conjugated VNP loaded in the hydrogel), VNP-GD/EI-NP@Gel (GSDMD protein cage-conjugated VNP and EI-NP co-loaded in the hydrogel) and VNP-GD/EI-NP@Gel+aPD-1 (GSDMD protein cage-conjugated VNP and EI-NP co-loaded in the hydrogel with three times systemic injection of aPD-1 on day 0, day 2 and day 4) and VNP-GD/EI-NP@Patch+aPD1 (GSDMD protein cage-conjugated VNP and EI-NP loaded in the cell patch with three times systemic injection of aPD-1 on day 0, day 2 and day 4). Data are presented as mean ± s.d. (n = 6 mice) and analyzed by Log-rank (Mantel-Cox) test. VNP-GD/EI-NP@Patch+aPD1 vs. VNP-GD@Gel: *P = 0.0204. VNP-GD/EI-NP@Gel+aPD1 vs. VNP-GD@Gel: *P = 0.0169. Source data are provided as a Source Data file.