TABLE 2.
Comparison between with and without obstructive ventilatory dysfunction in patients with IPF combined small airway dysfunction.
| O-IPF (FEV1/FVC <70%) | Non OIPF (FEV1/FVC >70%) | P | |
|---|---|---|---|
| Cases | 11 | 73 | |
| FEF25 pred% | 46.10 ± 24.12 | 70.14 ± 22.79 | 0.002 |
| FEF50 pred% | 29.56 ± 15.38 | 67.42 ± 19.37 | <0.001 |
| FEF75 pred% | 22.65 ± 11.99 | 42.49 ± 15.02 | <0.001 |
| MMEF pred% | 25.64 ± 14.55 | 47.73 ± 12.02 | <0.001 |
| Emphysema rate% | 2.38 ± 2.37 | 1.48 ± 3.26 | 0.380 |
| Fibrosis rate% | 13.30 ± 9.40 | 16.13 ± 11.40 | 0.437 |
| Median survival time (months) | 20 | 27 | 0.237 |
| SpO2% | 93.18 ± 3.57 | 94.43 ± 4.22 | 0.352 |
| FVC | 2.51 ± 0.77 | 2.12 ± 0.71 | 0.096 |
| FVC pred% | 73.10 ± 18.25 | 61.31 ± 19.12 | 0.052 |
| FEV1 | 1.57 ± 0.45 | 1.70 ± 0.51 | 0.462 |
| FEV1 pred% | 56.75 ± 16.72 | 61.52 ± 17.00 | 0.387 |
| DLcopred% | 52.94 ± 28.56 | 41.33 ± 24.23 | 0.152 |
| CPI index | 37.14 ± 20.52 | 52.56 ± 19.32 | 0.016 |
Airway obstruction was defined by a Tifeneau index FEV1/FVC <70%. Notes: Measurement data are presented as mean ± standard deviation (SD). O-IPF, combined obstructive and idiopathic pulmonary fibrosis. SpO2%, oxygen saturation of peripheral blood. SpO2 is the resting arterial oxygen saturation measured at fingertips. FVC, forced vital capacity; FVC% pred, the percentage of the actual FVC over the predicted FVC; FEV1, forced expiratory volume in one second; FEV1% pred, the percentage of the actual FEV1 over the predicted FEV1; DLco, diffusing capacity of the lung for carbon monoxide; DLco% pred, the percentage of the actual DLco over the predicted DLco. Fibrosis Rate and Emphysema Rate calculated by AI according to the system established by Li HP et al. FEF25 pred%, Forced expiratory flow at 25 of vital capacity; FEF50 pred%, Forced expiratory flow at 25 of vital capacity; FEF75 pred%, Forced expiratory flow at 75 of vital capacity; MMEF pred%, Maximal mid-expiratory flow; CPI, composite physiologic index. In 2002, Athol U. Wells and others proposed to use CPI, which combined chest CT and pulmonary functional parameters, to assess the severity of interstitial lung diseases (ILDs). A higher CPI represents a more severe ILD.